The Biological Roles of XBP1 Isoforms in Pathophysiology

XBP1- IGFBP3 Signaling Pathway Promotes NSCLC Invasion and ...

... role of XBP1 in non-small cell lung cancer (NSCLC) r ... Spliced or Unspliced, That Is the Question: The Biological Roles of XBP1 Isoforms in Pathophysiology.

Correlation Between Low Cytoplasmic Expression of XBP1 and the ...

XBP1 is involved in the unfolded protein response (UPR) pathway, a pathway that is activated to restore cellular homeostasis following endoplasmic reticulum (ER) ...

Anti-XBP1 antibody (ab37152) - Abcam

Constituents · PBS ; Immunogen. Synthetic Peptide within Human XBP1_HUMAN. The exact immunogen used to generate this antibody is proprietary information. Database ...

The UPRosome – decoding novel biological outputs of IRE1α function

To restore ER proteostasis, a highly conserved pathway is engaged, known as the unfolded protein response (UPR), triggering adaptive programs or ...

12-h clock regulation of genetic information flow by XBP1s - PLOS

Here, we show that in mouse liver, transcriptional regulation significantly contributes to the establishment of 12-h rhythms of mRNA expression in a manner ...

Androgen modulation of XBP1 is functionally driving part of the AR ...

Besides regulating genes to maintain ER function,. XBP1 also drives cell-type-specific gene expression profiles, such as the MIST gene in the myoblast cell line ...

The Unfolded Protein Response and Cell Fate Control

XBP1 was also shown to control intestinal epithelial cell function, where its deficiency results in chronic inflammation resembling Crown ...

controlling cell fate decisions under ER stress and beyond - UFRGS

and calnexin80, although the biological function ... TLR activation of the transcription factor XBP1 regulates innate immune responses in ...

The IRE1a-XBP1 pathway promotes T helper cell differentiation by ...

XBP1s regulates the expression of numerous target genes involved in ER biogenesis. Its role has been studied in secretory cells, such as ...

Neuronal dystonin isoform 2 is a mediator of endoplasmic reticulum ...

The present study therefore aims to elucidate underlying mechanisms of dt pathogenesis and to determine the individual roles of dystonin-a1 and ...

miR‐34c‐5p modulates X‐box–binding protein 1 (XBP1) expression ...

Disturbing homeostasis of the endoplasmic reticulum (ER), the central organelle for the synthesis, folding, and post-translational modification ...

Androgen modulation of XBP1 is functionally driving part of the AR ...

Both isoforms contain a. DNA-binding domain, but only XBP1s has a transactivation domain enabling transcriptional induction of UPR genes.

XBP1 Products - R&D Systems

The spliced form of XPB1 (XBP1S) is a 376 amino acid (aa), 55 kDa transcription factor essential for the unfolded protein response.

Drosophila XBP1 Expression Reporter Marks Cells under ... - PLOS

These results suggest that secretory cells suffer from inherent ER stress, and the xbp1p>dsRed flies provide a useful tool in studying the function and ...

ERN1 - Serine/threonine-protein kinase/endoribonuclease IRE1

The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes ...

XBP1 - Drugs, Indications, Patents - Patsnap Synapse

Functions as a negative feed-back regulator of the potent transcription factor XBP1 isoform 2 protein levels through proteasome-mediated degradation, thus ...

XBP1, Unfolded Protein Response, and Endocrine ... - DTIC

... XBP1(S) affects cell fate, evaluating the role of an ... Fig 3: Autophagy is enhanced upon FAS treatment and/or XBP1 over-expression in ER+ breast cancer cell ...

The UPRosome – decoding novel biological outputs of IRE1α function

The resulting spliced XBP1 protein (XBP1s) acts as a potent transcription factor that controls the upregulation of several. UPR genes involved in protein ...

The ER stress factor XBP1s prevents amyloid-b neurotoxicity

death induced by Ab in both models when XBP1 was elimi- nated, suggesting a physiological role in AD pathogenesis. This protective activity ...

Pathogenic proteotoxicity of cryptic splicing is alleviated by ... - Science

To determine whether lack of USP39 function phenocopies the pathogenesis of spliceosome-associated diseases, we first generated usp39-deficient ...