The Biology of YAP/TAZ

Multifaceted regulation and functions of YAP/TAZ in tumors (Review)

Notably, whether YAP has biological activity or not depends on the location of YAP in cells. Phosphorylated YAP binds to the 14-3-3 protein in ...

An overview of signaling pathways regulating YAP/TAZ activity

Presently, it is known that YAP/TAZ also interact with various non-Hippo signaling pathways, and have diverse roles in multiple biological processes, including.

An overview of signaling pathways regulating YAP/TAZ activity

Presently, it is known that YAP/TAZ also interact with various non-Hippo signaling pathways, and have diverse roles in multiple biological ...

dNTP metabolism links mechanical cues and YAP/TAZ to cell growth ...

YAP/TAZ, downstream transducers of the Hippo pathway, are powerful regulators of cancer growth. How these factors control proliferation ...

Evolutionary History of YAP and the Hippo/YAP Pathway

This suggests that the TAZ gene probably originated from gene duplication of YAP in early vertebrates. The conserved nature of the WW1 domain in ...

Induction of AP-1 by YAP/TAZ contributes to cell proliferation and ...

Our study uncovers a functional interplay between immediate early gene transcription and Hippo biology. Results. YAP/TAZ in regulating immediate early genes in ...

Peritumoral activation of the Hippo pathway effectors YAP and TAZ ...

When active, YAP and TAZ accumulate in the nucleus and, through their binding to transcription factors such as TEAD, they regulate the ...

Cell phenotypic plasticity requires autophagic flux driven by YAP ...

YAP/TAZ are downstream effectors of cellular mechanotransduction and indeed we found that cell mechanics, dictated by the physical property of ...

AR activates YAP/TAZ differentially in prostate cancer

YAP and TAZ do not bind to DNA directly and consequently make use of transcription factors to regulate gene expression, most notably via the ...

YAP/TAZ (E9M8G) Rabbit mAb #93622 - Cell Signaling Technology

YAP/TAZ (E9M8G) Rabbit mAb recognizes endogenous levels of total YAP and TAZ proteins. Species Reactivity: Human, Mouse, Rat, Monkey. Source / Purification.

The YAP/TAZ Pathway in Osteogenesis and Bone Sarcoma ... - MDPI

YAP and TAZ are intracellular messengers communicating multiple interacting extracellular biophysical and biochemical cues to the transcription apparatus in ...

YAP/TAZ as a Novel Regulator of cell volume - bioRxiv

Based on the idea that YAP/TAZ is a mechanosensor, we find that inhibiting the assembly of myosin and cell tension slows cell cycle progression ...

The Biology of YAP/TAZ: Hippo Signaling and Beyond - EBSCO

The Biology of YAP/TAZ: Hippo Signaling and Beyond · Piccolo, Stefano; Dupont, Sirio; Cordenonsi, Michelangelo · Physiological Reviews, 2014, Vol 94, Issue 4, ...

The Hippo Pathway and YAP/TAZ–TEAD Protein–Protein Interaction ...

(26-28) The TEAD family transcription factors are the main YAP/TAZ partners in the regulation of gene expression. Knockdown of TEADs or ...

The Hippo signaling pathway in stem cell biology and cancer

GPCR signaling can either stimulate or inhibit YAP/TAZ activity in a manner dependent on the coupled G‐protein. For example, activation of G12/13 or Gq/11 ...

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway ...

2010). However, the biological signif- icance of this potential negative feedback regulation had not been fully explored. Furthermore, although the evolu-.

The Hippo Pathway: Biology and Pathophysiology - Annual Reviews

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling ...

YAP/TAZ deficiency reprograms macrophage phenotype ... - PLOS

Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are the key mediators of the Hippo signaling pathway ...

Context-dependent roles of YAP/TAZ in stem cell fates and cancer

YAP and TAZ are notable in their ability to change both cell fate and survival. Depending on the context, they can either maintain a stem or ...

YAP/TAZ Transcriptional Targets Antibody Sampler Kit #56674

Background. YAP and TAZ (WWTR1) are transcriptional co-activators that play a central role in the Hippo Signaling pathway that regulates cell, tissue and organ ...