The genomic definition of high|risk myeloma

Paper: Risk Assignment Using the Myeloma Genome Project Panel

A subset of patients with multiple myeloma (MM), termed â€œhigh-riskâ€ , have high rates of early relapse and short survival. The definition of high-risk (HR) ...

CoMMpass Data Continue to Shape Understanding of Genomic ...

Even in high-risk multiple myeloma, the disease is never more ... As we define risk in myeloma, it is often dependent on the treatment ...

A validated gene expression model of high-risk multiple myeloma is ...

To molecularly define high-risk disease, we performed microarray analysis on tumor cells from 532 newly diagnosed patients with multiple ...

Genomic Profiling to Contextualize the Results of Intervention for ...

Early intervention for high-risk smoldering multiple myeloma (HR-SMM) achieves deep and prolonged responses. It is unclear if beneficial outcomes are due to ...

Integrative multi-omics identifies high risk multiple myeloma ...

This high-risk group presents diverse previously known genetic markers, but also a new characteristic defined by accumulation of genomic loss.

Role of Whole-Genome Sequencing in Identifying Patients With ...

Clinicians use a variety of tests to detect an abnormal protein associated with the disease. Patients with high protein levels are at higher ...

Identifying high‐risk multiple myeloma patients: A novel approach ...

Multiple myeloma (MM) is a heterogeneous hematopoietic malignancy that arises from uncontrolled neoplastic proliferation of plasma cells in the ...

Identification of Prognostically Relevant Chromosomal ...

Multiple myeloma (MM) is a clonal B-cell neoplasia characterized by malignant plasma cells, which accumulate in the bone marrow, producing a monoclonal ...

Four genes predict high risk of progression from smoldering to ...

Patients with SMM seen at the Myeloma Institute for Research and Therapy were included in a prospective, observational clinical trial (SWOG ...

[PDF] Genomics of Multiple Myeloma. | Semantic Scholar

The most interesting data have demonstrated subclonality in all patients with MM, including subclonal mutations of supposed driver genes KRAS, NRAS, ...

FAQs on Biomarkers in Multiple Myeloma - MMRF - Facebook

... high, people tend not to respond as well. That doesn't mean you ... the genomes of those minor cells. Um allow us to not only sequence ...

MMRF CoMMpass Study & CureCloud® | Personalized Treatment

CoMMpass is one the largest myeloma datasets in the public domain. It focuses on mapping the genomic landscape of myeloma to understand patient subtypes, risk ...

Genomic Basis of Multiple Myeloma Subtypes from the MMRF ...

Consensus clustering identified 8 and 12 unique copy number and expression subtypes of myeloma, respectively, identifying high- risk genetic ...

My paper of the month - Genomic Classification and Individualized ...

... define a double high risk group(3). In search for a more robust and ... risk for newly diagnosed myeloma (IRMMa). The study consists of ...

757 Genomic Profiling to Interpret the Outcomes of Early Intervention ...

Early intervention for High-Risk Smoldering Multiple Myeloma (HR-SMM) achieves deeper and more prolonged responses compared to Newly Diagnosed ( ...

Defining high-risk myeloma: exciting updates and their implications

This new consensus will improve clinical trial design and enhance patient outcomes by incorporating advanced diagnostic tools like whole genome ...

Integrative multi-omics identifies high risk Multiple Myeloma ...

... define genomic subgroups independently from known clinical features. We further explored the molecular features and clinical associations of ...

The Cancer Genome Atlas Program (TCGA) - NCI

... multiple institutions. Over the next dozen years, TCGA generated over 2.5 petabytes of genomic, epigenomic, transcriptomic, and proteomic data. The data ...

Using Genomics to Identify High-Risk Myeloma after Autologous ...

Multiple myeloma is a malignancy of antibody-secreting plasma cells that expand in the bone marrow. Although high-dose therapy/autologous stem cell ...

Cytogenetic Abnormalities in Multiple Myeloma: Incidence ...

High-risk MM is defined as having at least one of the cytogenetic abnormalities related with poor prognosis, which include IGH translocations t( ...