Transcription|Replication Collisions and Chromosome Fragility

Mechanisms of Oncogene-Induced Replication Stress

GIN can result from changes in the number or structure of chromosomes (chromosomal instability), changes in the number of oligonucleotide repeats in ...

Transcription--replication conflicts: how they occur and - CORE

chromosome fragility at sites of S phase transcription. Cell ... transcription-replication collisions, which can manifest as different forms of fragility.

Transcription-replication conflicts as a source of common fragile site ...

... collisions between transcription and replication ... Transcription-replication conflicts at chromosomal fragile sites-consequences in M phase and beyond.

DNA replication stress: oncogenes in the spotlight - SciELO

DNA structures to chromosome replication and fragility ... replication fragile sites: Where replication-transcription collisions cause genetic instability.

Dicer prevents genome instability in response to replication stress

... replication collisions to maintain genome ... replication forks, leading to enhanced chromosome fragility and accumulation of 53BP1 bodies.

Replication stress and genome rearrangements: lessons from yeast ...

Helmrich A, Ballarino M, Tora L: Collisions between replication ... chromosome fragility at repressed genes due to the hypo-acetylated chromatin.

Mrc1 and Tof1 Regulate DNA Replication Forks in Different Ways ...

The progression of DNA replication forks is also regulated in diverse ways during the normal process of chromosome replication, and this allows ...

RECQ5 helicase promotes resolution of conflicts between ...

... genome-stabilizing effect by acting at sites of replication-transcription collisions. ... replicating fragile sites that contribute to genome ...

How DNA protein machines collide head-on and stop replication

A new study describes how head-on collisions between protein machines on chromosomes can disrupt DNA replication and boost the rate of gene mutations.

RNA polymerase II contributes to preventing transcription‐mediated ...

Collisions between RNA transcription and DNA replication ... chromosome fragility at sites of S phase transcription. Cell 138 ...

Processing DNA lesions during mitosis to prevent genomic instability

... transcription–replication collisions. [63–65]. In line with ... fragile sites during DNA replication stress. Open Biol. 8,. 180018 ...

Transcription shapes DNA replication initiation to preserve genome ...

Mechanistically, we find that RNA polymerase II actively redistributes the chromatin-bound mini-chromosome maintenance complex (MCM), but not ...

Chromosomal fragile site - Wikipedia

They are often susceptible to spontaneous breakage during replication, frequently affecting neighboring genes. Clinically, the most important rare fragile site ...

Chapter 9: DNA Replication - Chemistry - Western Oregon University

... chromosome until replication is complete. ... Replication termination typically occurs by the collision of two replication forks anywhere between two active ...

Stephen P. Bell (MIT / HHMI) 1a: Chromosomal DNA Replication

https://www.ibiology.org/genetics-and-gene-regulation/mechanisms-chromosomal-dna-replication/ Part 1a: Mechanisms of Chromosomal DNA ...