Tumor|Induced Local and Systemic Impact on Blood Vessel Function

Metastasis from the tumor interior and necrotic core formation are ...

This uncovered a sharp rise in circulating tumor cell (CTC) abundance associated with necrosis and changes in the blood vessels. Gene expression ...

The Role of Angiogenesis in Cancer Treatment - MDPI

Endogenous local or systemic chemical signals coordinate functions of endothelial cells and smooth muscle cells to repair damaged blood vessels. The generation ...

Brain Tumors - AANS

... local blood supply intended for normal tissue. Tumors can produce substances called angiogenesis factors that promote the growth of blood vessels. The new ...

Direct Vascular Effects of Furosemide in Humans - AHA Journals

Thus, up to now it is unknown whether furosemide-induced effects on systemic ... In contrast, we observed no effect of local furosemide on ...

Non-Small Cell Lung Cancer Treatment (PDQ®) - NCI

... Impact of radical systematic mediastinal lymphadenectomy on tumor staging in lung cancer. ... tumors that had major blood vessel ...

Tumor microenvironment: blood vascular system in cancer metastasis

Pathological angiogenesis plays a significant role in the progression of various cancers. An extensive body of evidence generated over a period of several ...

Extratumoral Vascular Invasion Is a Significant Prognostic Indicator ...

The presence of vascular invasion was determined by identifying conspicuous clusters of intravascular cancer surrounded by an elastic layer. Since August 2001, ...

Real-Time Imaging Reveals Local, Transient Vascular Permeability ...

VEGFA is known to promote vascular permeability, and inhibition of VEGFA results in the normalization of tumor vasculature and a decrease in ...

contribution of endothelial progenitor cells to angiogenesis and ...

(cont.) The hypothesis that unusual tumor blood vessel morphology is caused by solid mechanical interactions is investigated experimentally. Blood vessels in ...

The effect of aerobic exercise on tumour blood delivery: a systematic ...

Tumour blood vessels are structurally and functionally abnormal, resulting in areas of hypoxia and heterogeneous blood supply.

How Cancer Spread Leads to Leaky Blood Vessels

Blood vessels in tumor tissues are leakier than those in normal tissues. Researchers from the University of Michigan-Dearborn, ...

Your blood, bone marrow and cancer drugs

Cancer drugs can affect your bone marrow and blood causing: an increased risk of infection; bruising and bleeding; breathlessness.

Evidence for Direct Local Effect of Angiotensin in Vascular ... - JCI

Ang II is generated via an enzymatic cascade in which tissue angiotensin converting enzyme (ACE) plays a key role (17-19). We postulate that increased vascular ...

Vasodilation - Wikipedia

Vasodilation, also known as vasorelaxation, is the widening of blood vessels. It results from relaxation of smooth muscle cells within the vessel walls, ...

The role of hypoxia in the tumor microenvironment and development ...

Chronic hypoxia occurs when the tumor cells expand beyond 70 µm from the pre-existing nutritive blood vessels, which prevents an adequate ...

Vascular‐targeting therapies for treatment of malignant disease

Biologic approaches and small-molecule drugs that can be used to damage tumor vasculature have been identified. Physiologic, histologic/ ...

Spread of Cancer Causes Leaky Blood Vessels in Tumor Tissue

Blood vessels in tumor tissues are leakier than those in normal tissues. Researchers from the University of Michigan-Dearborn, ...

The role of hypoxia in cancer progression, angiogenesis, metastasis, a

Neovasculogenesis maintains blood flow to the growing tumor tissue that expands rapidly, providing nutrients and oxygen for thriving cancer ...

How Endothelial Cells Adapt Their Metabolism to Form Vessels in ...

Figure 2. Metabolic regulation of tumor vessel normalization. (A) In abnormal tumor vessels, endothelial cells (ECs) form weak junctions that, ...

Soft Tissue Sarcoma Types, Staging and Treatment

Blood. The cancer gets into the blood, travels through the blood vessels, and forms a tumor (metastatic tumor) in another part of the body.