Un|gating and allosteric modulation of a pentameric ligand ...

Regulation of a pentameric ligand-gated ion channel by a ...

This work details type-specific lipid interactions, which adds to our growing understanding of how lipids modulate pLGICs.

A Gating Mechanism of Pentameric Ligand-gated Ion Channels

... gated chloride channel from Caenorhabditis elegans (GluCI), whose openchannel structure was detd. complexed with the pos. allosteric modulator ivermectin.

Allosteric modulation of pentameric ligand-gated ion channels

Allosteric modulation of pentameric ligand-gated ion channels. Charles L. C. Smelt. September 2018. A thesis presented for the degree of Doctor of Philosophy ...

Allosteric regulation of pentameric ligand-gated ion channels - HAL

A cyan sphere shows the location of the allosteric Ca2+ binding site for the modulation of pLGICs by divalent cations. The coordinates of the ...

Druggable lipid binding sites in pentameric ligand-gated ion ...

However, it is intriguing that many of these lipid binding sites are also known sites for other allosteric modulators or drugs, supporting the ...

Mutational analysis to explore long-range allosteric couplings ... - eLife

Pentameric ligand-gated ion channels (pLGICs) mediate chemical signaling through a succession of allosteric transitions that are yet not ...

Vestibular Modulation by Stimulant Derivatives in a Pentameric ...

Abstract. Allosteric modulation of pentameric ligand-gated ion channels (pLGICs) is crit- ical to the action of neurotransmitters and many ...

Genuine open form of the pentameric ligand-gated ion channel GLIC

Pentameric ligand-gated ion channels (pLGICs) mediate fast chemical ... allosteric modulation (Nury et al., 2011 [Nury, H., Van Renterghem, C., Weng ...

Recent Insight into Lipid Binding and Lipid Modulation of ... - MDPI

Structural basis for allosteric transitions of a multidomain pentameric ligand-gated ion channel. Proc. Natl. Acad. Sci. USA 2020, 117 ...

A chimeric prokaryotic pentameric ligand–gated channel reveals ...

However, the conformational dynamics and structural rearrangements that underlie gating and allosteric modulation remain poorly understood.

Modulation of a model ligand- gated ion channel by amphetamine ...

Structural basis for a bimodal allosteric mechanism of general anesthetic mod- ulation in pentameric ligand-gated ion channels. Cell reports 23: 993–1004.

Ligand-gated ion channels

Modulation of gating can occur by the binding of endogenous, or exogenous, modulators to allosteric sites. LGICs mediate fast synaptic transmission, on a ...

A chimeric prokaryotic pentameric ligand–gated channel reveals ...

However, the conformational dynamics and structural rearrangements that underlie gating and allosteric modulation remain poorly understood. We used a ...

Opposing Effects of the Anesthetic Propofol at Pentameric Ligand ...

... modulating agonist responses of pentameric ligand-gated ion channels (pLGICs). ... allosteric role of S18′ in propofol enhancement of ...

Allosteric Activation and Modulation of Pentameric Ligand-gated Ion ...

Allosteric Activation and Modulation of Pentameric Ligand-gated Ion. Channels. Eukaryotic Cys-loop receptors control fast synaptic transmission and are ...

Ligand-gated ion channels articles within Nature Communications

Conformational transitions and allosteric modulation in a heteromeric ... Pentameric ligand-gated ion channels are modulated by anionic phospholipids.

Pentameric Ligand-Gated Ion Channels | Encyclopedia MDPI

pLGICs are also targeted by a variety of exogenous molecules that allosterically modulate the agonist-induced response in a manner that alters ...

Functional, biochemical and structural characterisation of ... - Lirias

Pentameric ligand-gated ion channels (pLGICs) are of high clinical ... Insights in allosteric modulation of pLGICs are notably interesting as ...

Allosteric modulation of pentameric receptor channels and ...

Tiselius symposium Keynote lecture “Molecular dynamics of ligand-gated ion channels: from signal transduction to allosteric modulation: ...

Photoaffinity Labeling of Pentameric Ligand-Gated Ion Channels

In this chapter, we discuss practical aspects of experimental strategies to identify allosteric modulator binding sites in pLGIC using ...