- Development of a framework and decision tool for the evaluation of ...🔍
- Statistical Challenges in the Identification🔍
- Assessment of clinically relevant bleeding as a surrogate outcome ...🔍
- Evaluating relapse|free survival as an endpoint for overall survival in ...🔍
- validation of surrogate endpoints in advanced solid tumours🔍
- Disease|free survival as surrogate for overall survival in real|world ...🔍
- Validation of the Surrogate Threshold Effect for Change in Bone ...🔍
- ASSOCIATION BETWEEN HAZARD RATIOS OF SURROGATE ...🔍
Validation of the Surrogate Threshold Effect for Change ...
Development of a framework and decision tool for the evaluation of ...
... change in surrogate and outcome undertaken in the ... Surrogate threshold effect: An alternative measure for meta-analytic surrogate endpoint validation.
Statistical Challenges in the Identification, Validation, and Use of ...
Statistical research on surrogate markers is an active area of intense research. Surrogate markers are used across many different subject areas.
Assessment of clinically relevant bleeding as a surrogate outcome ...
... changes in the true outcome, i.e. that ... ∙ Buyse, M. Surrogate threshold effect: an alternative measure for meta‐analytic surrogate endpoint validation.
Evaluating relapse-free survival as an endpoint for overall survival in ...
The surrogate threshold effect for RFS was 0.86. Consistent results were confirmed in several sensitivity analyses based on different trial phases, experimental ...
validation of surrogate endpoints in advanced solid tumours
... surrogate (i.e., the change on the surrogate ... Surrogate threshold effect: an alternative measure for meta-analytic surrogate endpoint validation.
Disease-free survival as surrogate for overall survival in real-world ...
censored) once a change in plan coverage occurred. ... Surrogate threshold effect: an alternative · measure for meta-analytic surrogate endpoint validation.
Validation of the Surrogate Threshold Effect for Change in Bone ...
Validation of the Surrogate Threshold Effect for Change in Bone Mineral Density as a Surrogate Endpoint for. Fracture Outcomes: The FNIH ...
ASSOCIATION BETWEEN HAZARD RATIOS OF SURROGATE ...
In trial-level endpoint validation studies, the association between treatment effect ... estimating surrogate threshold effect (STE), and reported results and/or ...
Surrogate endpoints – Overcoming reimbursement and validation ...
... surrogacy endpoint validation performed? - We also dive deep into an analysis of treatment effect correlation and work through a case study ...
The individual-level surrogate threshold effect in a causal
... change in E(ΔT|ΔS0) when ΔS0 ... Surrogate threshold effect: an alternative measure for meta-analytic surrogate endpoint validation.
Validity of Surrogate Endpoints and Their Impact on Coverage ...
We extracted data on the methods applied for surrogate validation. We assessed the level of agreement between agencies and fitted mixed-effects logistic ...
Evaluation of Progression-Free Survival as a Surrogate Endpoint for ...
Therefore, the surrogacy of PFS and response rate with OS (i.e., the prediction of OS) is dependent on the correlation between the treatment's effect on the ...
How to use frailtypack for validating failure-time surrogate endpoints ...
We recall in the S1B and S1C Appendix in S1 Appendix the formulation of these associa- tion measures. Prediction and surrogate threshold effect ...
Therefore, they propose “before offering an intervention on the basis of effects on a surrogate outcome, the clinician should note a consistent relation between ...
Time to review the role of surrogate endpoints in health policy
Surrogate threshold effect: an alternative measure for meta-analytic surrogate endpoint validation. ... treatment-induced changes on the surrogate (i.e. ...
early breast cancer: A correlation analysis
The surrogate threshold effect (Burzykowski T, Buyse M. Pharm Stat. 2006;5:173–186) was 0.82 for DFS/OS HR. Scenario analysis (n = 9 RCTs), ...
Meta-Analysis of Candidate Surrogate End Points in Advanced ...
... surrogate threshold effect. The log base for these equations is 10. NEJM EVIDENCE. 7. For personal use only. No other uses without permission ...
Predicting Treatment Effect from Surrogate Endpoints and - jstor
of not depending on a standard of care that can change over ... Surrogate threshold effect: An alternative for meta- analytic surrogate endpoint validation.
Systematic Review and Recommendation for Reporting of Surrogate ...
M. Surrogate threshold effect: an alternative measure for meta-analytic surrogate endpoint validation ... You can change your cookie ...
Surrogate Endpoints in Health Technology Assessment
process of biomarker validation”, they quote correlation of the effects on the surrogate and the ... Surrogate threshold effect: an alter- native ...