Wnt/β‑catenin pathway activation and silencing of the APC gene in ...

Prickle-1 Negatively Regulates Wnt/β-Catenin Pathway by ...

Background & Aims: Aberrant activation of Wnt signaling due to accumulation of β-catenin has been linked to tumorigenesis. Mutations of β-catenin, APC, ...

Blocking the WNT/β-catenin pathway in cancer treatment ...

The WNT/β-catenin signaling pathway plays crucial roles in tumorigenesis and relapse, metastasis, drug resistance, and tumor stemness maintenance.

Cepharanthine suppresses APC-mutant colorectal cancers by down ...

The aberrant activation of the Wnt/β-catenin signaling pathway is closely associated with the development of various carcinomas, ...

Targeting Wnt signaling in colorectal cancer. A Review in the Theme

Loss of the Wnt pathway negative regulator adenomatous polyposis coli (APC) is the hallmark of human colorectal cancers (CRC). Recent advances in high- ...

Wnt3a/β-Catenin/CBP Activation in the Progression of Cervical ...

Accumulating evidence suggests that the Wnt/β-catenin signaling pathway serves critical functions in the sequential development of the ...

The crosstalk between microRNAs and the Wnt/β-catenin signaling ...

The aberrant expression profile of miRs was in part due to the constitutive activation of Wnt pathway in a plethora of cancers. β-catenin ...

LRP5 Promotes Gastric Cancer via Activating Canonical Wnt/β ...

The overactivation of canonical Wnt/β-catenin pathway is one of the main cascades for the initiation, progression, and recurrence of most ...

mutant colorectal cancer is dependent on Wnt/beta-catenin ...

In this study, we provide evidence that Wnt/β-catenin pathway activation is required for maintenance of colorectal tumors harboring APC mutations. We show that ...

The WNT/β‐catenin dependent transcription: A tissue‐specific ...

β-catenin-mediated Wnt signaling is an ancient cell-communication pathway in which β-catenin drives the expression of certain genes.

Multiple Targets of the Canonical WNT/β-Catenin Signaling in Cancers

Activating the mutated β-catenin pathway initiates the gene expression of interferon regulatory factor 8 (IRF8) that leads to differentiation and expansion of ...

Truncated APC in colon cancer cells is functional. (a) Silencing of...

The Wnt/β-catenin pathway involves proteins that are mutated in more than 90% of CRC patients, and hyperactivation of β-catenin signaling is induced through ...

Epigenetic Activation of Wnt/β-Catenin Signaling in NAFLD ... - MDPI

Activation of Wnt/β-catenin signaling can drive the expression of specific oncogenes in various human cancers. CTNNB1, APC and AXIN gene mutations are classic ...

Activation of Wnt/β-catenin signaling is critical for the tumorigenesis ...

Increased activation of the Wnt/β-catenin pathway in ChP organoids, through treatment with a potent GSK3β inhibitor, reduced the differentiation ...

WNT/β-catenin pathway activation in hepatocellular carcinoma: a c

The WNT/β-catenin pathway plays crucial roles in many diverse cellular processes, including cell proliferation, cell fate decision, cell ...

Wnt/ß-Catenin and MAPK Signaling - Hubrecht Institute

Mutations in the genes encoding β-catenin, Axin, or APC, which occur in di- verse human tumors, lead to accumulation of β-catenin and transactivation of TCF/.

Wnt signaling - WormBook

A major effector of the canonical Wnt signaling pathway is the transcription factor β-catenin (Armadillo in flies; Figure 1). In the absence of ligand, ...

Tissue-Specific Effects of Reduced β-catenin Expression on ... - PLOS

The APC protein regulates the β-catenin protein pool that functions as a co-activator of T cell factor (TCF)-regulated transcription in Wnt pathway signaling.

Article Details - Wnt/β‑catenin pathway activation and silencing...

Mutations or epigenetic inactivation of the tumor suppressor adenomatous polyposis coli (APC), the two acting as prominent oncogenic mechanisms in a number of ...

The role of the class I Wnt pathway antagonist sFRP4 in colorectal ...

To date, a variety of Wnt/β-catenin pathway-related target genes have been discovered. ... Blocking Wnt signaling pathway activity inhibits colon ...

WNT/β-catenin pathway activation in hepatocellular carcinoma

The WNT/β-catenin pathway plays crucial roles in many diverse cellular processes, including cell proliferation, cell fate decision, cell ...