- The Interaction Properties of the Human Rab GTPase Family🔍
- Quantitative image analysis approaches for probing Rab GTPase ...🔍
- Large|Scale Profiling of Rab GTPase Trafficking Networks🔍
- Small Rab GTPases in Intracellular Vesicle Trafficking🔍
- Mechanisms of action of Rab proteins🔍
- Rab GTPases as Physiological Substrates of LRRK2 Kinase🔍
- RAB32 Ser71Arg in autosomal dominant Parkinson's disease🔍
- Increased Myocardial Rab GTPase Expression🔍
Analysis of rab GTPases.
The Interaction Properties of the Human Rab GTPase Family - PLOS
The Rab protein is geranyl-geranylated near the C-terminus to enable membrane binding. Guanine nucleotide exchange factor proteins (GEFs) accelerate the GDP to ...
Rab proteins generally possess a GTPase fold, which consists of a six-stranded beta sheet which is flanked by five alpha helices. Rab GTPases regulate many ...
Quantitative image analysis approaches for probing Rab GTPase ...
Their importance is further underlined by the ever increasing number of diseases being attributed to Rab protein dysfunction [3]. One hallmark ...
Large-Scale Profiling of Rab GTPase Trafficking Networks
Rab GTPases and SNARE fusion proteins direct cargo trafficking through the exocytic and endocytic pathways of eukaryotic cells. We have used steady state ...
Small Rab GTPases in Intracellular Vesicle Trafficking - ProQuest
Small Rab GTPases, the largest group of small monomeric GTPases, regulate vesicle trafficking in cells, which are integral to many cellular processes.
Mechanisms of action of Rab proteins, key regulators of intracellular ...
Rab proteins are GTPases that act as key regulators in intracellular vesicular transport. Like other GTPases of the Ras family, they switch between the ...
Rab GTPases as Physiological Substrates of LRRK2 Kinase
The Rab GTPases regulate vesicle trafficking, suggesting that LRRK2 may be a regulator of such vesicle trafficking, confirming previously ...
RAB32 Ser71Arg in autosomal dominant Parkinson's disease
The RAB GTPases are regulators and substrates of LRRK2, and variants in the LRRK2 gene are important risk factors for Parkinson's disease. We ...
Increased Myocardial Rab GTPase Expression | Circulation Research
The Ras-like Rab GTPases regulate vesicle transport in endocytosis and exocytosis. We found that cardiac Rabs1, 4, and 6 are upregulated in ...
Systematic Discovery of Rab GTPases with Synaptic Functions in ...
analyzed here exhibit neuron-specific or strongly neuron-en- riched expression. Neuronal Rabs are present in all major branches of the phylogenetic tree, and ...
Identification of a GDI displacement factor that releases endosomal ...
Prenylated Rab GTPases occur in the cytosol in their GDP‐bound conformations bound to a cytosolic protein termed GDP‐dissociation inhibitor (GDI).
Role of Rab family GTPases and their effectors in melanosomal ...
Ohbayashi, Norihiko; Fukuda, Mitsunori · Rab GTPases constitute a family of small GTPases that regulate a variety of membrane trafficking events in all ...
This fundamental study addresses the regulation of the MICAL-family of actin regulators by Rab GTPases important for directing membrane ...
Reviewer #2 (Public review):. Summary: Rai and coworkers have studied the regulation of the MICAL-family of actin regulators by Rab 8 family ...