Carboplatin dosing in the era of IDMS|creatinine

Comparative Study of Carboplatin Dosing in Lung Cancer Patients ...

Compared with mean prescribed carboplatin dose (444.4 mg), its mean estimated doses by Cockcroft-Gault, Jelliffe, MDRD, and J-MDRD formulae were ...

Carboplatin: Package Insert / Prescribing Information - Drugs.com

Patients with creatinine clearances of approximately 60 mL/min or greater excrete 65% of the dose in the urine within 12 hours and 71% of the ...

Carboplatin versus cisplatin - Annals of Oncology

So, per mole, carboplatin induced 20 times less Pt-GG adduct that cisplatin. Both the preclinical data and the clinical research data suggest that dose may be ...

Evaluation of carboplatin dosing in non-small cell lung carcinoma ...

Physicians tended to lower the prescribed dose (32.2% of the cycles) by using a higher serum creatinine (Scr) level for dose calculation than ...

NCCP Regimen 251 CARBOplatin AUC 4-6 28days - HSE

Carboplatin dosing in overweight and obese patients with normal renal ... Updated CARBOplatin infusion time. Updated. CARBOplatin dose ...

Carboplatin Dosing in Overweight and Obese Patients

Serum creatinine (SCr)-based formulas are used to estimate GFR when calculating carboplatin dosage with the Calvert formula. Individualized dosing is the ...

Evaluation of creatinine-based formulas in dosing adjustment of ...

We previously showed that the CG and MDRD formulas have similar accuracy for carboplatin dosing in patients with gynecological malignancies. We now examine ...

Carboplatin Dosing Accounting for the Renal and Hematologic ...

The pharmacokinetics of a drug can be il- lustrated graphically by plotting the serum drug concentration level versus time after drug administration. The shaded ...

Prediction of carboplatin clearance calculated by patient ...

(Calvert formula) dose (mg) = area under the plasma concentration versus time curve (AUC) · [glomerular filtration rate (GFR) + 25]. Creatinine clearance (Ccr), ...

How to Assess Renal Function for Dosing Carboplatin

At that time, the HOPA Research Committee had already initiated a survey for carboplatin dosing to determine practice patterns. As such, the decision was made ...

Variability of carboplatin dose calculation methods in Spain

part time and full time pharmacists. Cuesta et al. 3. Page 4. germ-cell ... study on aging: impact on renal drug dosing. Pharmacotherapy 2013; 33: 912–921.

pharmacokinetics of carboplatin after adjusted dosing for high bmi ...

concentration-time curve (AUC) of carboplatin after adjusted dosing ... carboplatin after adjusted dosing for high BMI, low serum creatinine, and.

Continuous ambulatory peritoneal dialysis: pharmacokinetics and ...

Beijnen JH (2006) Flat dosing of carboplatin is justified in adult patients with normal renal function. Clin Cancer Res 12:6502–. 6508. 10. el ...

Carboplatin Accord Injection - Medsafe

Cortical blindness has been reported in patients with impaired renal function receiving high-dose carboplatin. ... time after ceasing.

Survey on the Usage of the Calvert Formula to Calculate AUC ...

As the area under the concentration-time curve (AUC) of free carboplatin is related with efficacy and toxicity following carboplatin administration, carboplatin ...

Dosing carboplatin in patients assigned to hemodialysis - Healio

Renal function is inherently adjusted for in the Calvert equation, in which the suggested carboplatin dose in milligrams is dependent on the ...

carboplatin injection Clinical Pharmacology - US

In patients with creatinine clearances of about 60 mL/min or greater, plasma levels of intact carboplatin decay in a biphasic manner after a 30-minute ...

Overestimation of carboplatin doses is avoided by radionuclide GFR ...

... period were selected; eGFR was calculated using the Modification ... the GFR and the calculated carboplatin dosage at low serum creatinine values.

CARBOPLATIN DOSING FOR ADULT JAPANESE PATIENTS

In the European Union and perhaps other countries, the measurement of serum creatinine has yet to be standardized.8). The time-lag between Japan and other ...

Carboplatin Calculator

How do I calculate the carboplatin dose if the target AUC is 5? · Take the GRF value, in this case 100, and add 25. · Take the number calculated ...