Chromothripsis in cancer

The landscape of chromothripsis across adult cancer types

We show that chromothripsis affects a substantial proportion of human cancers, with a prevalence of 49% across all cases. Chromothripsis generates entity- ...

City Research Online - City, University of London

... Cancer Genome Atlas (TCGA), we analyze pat- terns of chromothripsis across 2,658 tumors from 38 cancer types using whole-genome sequencing data. We find ...

Pathway tied to cancer-driving genome alterations identified

Chromothripsis allows cancer cells to rapidly evolve their genomes by extensively rearranging individual chromosomes, leading to multiple ...

Chromothripsis drives the evolution of gene amplification in cancer.

Chromothripsis is a major driver of circular extrachromosomal DNA (ecDNA) amplification (also known as double minutes) through mechanisms that depend on poly( ...

causes and consequences of chromosome shattering.

Chromothripsis and cancer: causes and consequences of chromosome shattering. Abstract: Genomic alterations that lead to oncogene activation and ...

Chromothripsis is linked to TP53 alteration, cell cycle impairment ...

2 In comparison to recent reports,8 the incidence of 35% rearrangement patterns in CK-AML is higher than in other tumor entities. Fifteen of the ...

Full article: Pathways to chromothripsis - Taylor & Francis Online

The comprehensive genetic analysis of many types of tumors has revealed a continuum of alterations to the cancer cell genome, ranging from single nucleotide ...

Criteria for Inference of Chromothripsis in Cancer Genomes - CORE

Introduction. Often described as a disease of the genome, cancer typically results from the acquisition of DNA alterations in somatic cells.

Chromothripsis and chromoplexy in myeloma - YouTube

Gareth Morgan, MD, PhD, FRCP, FRCPath, NYU Langone Medical Center, New York, NY, discusses chromothripsis ... Aspirin and cancer: the emerging ...

Chromosomal rearrangements and their neoantigenic potential in ...

In this analysis subjects with mesothelioma in The Cancer Genome Atlas (TCGA) were classified by the presence of 0–2 chromothripsis-like patterns (CTLPs) (n=64) ...

Micronuclei-based model system reveals functional consequences ...

Chromothripsis, a frequent phenomenon in cancer genomes, enables cancer cells to generate rapid and massive changes in their chromosomal ...

Chromothripsis identifies a rare and aggressive entity among newly ...

Our results obtained in a large cohort of newly diagnosed MM patients indicate that chromothripsis occurs in a hematopoietic cancer known ...

Chromosomal catastrophe is a frequent event in clinically ...

The degree of chromothripsis did not increase significantly in tumors of advanced grades and did not appear to contribute to tumor progression. Our data showed ...

Copy number variations and constitutional chromothripsis (Review)

Chromothripsis is a phenomena of chromosomal rearrangement following chromosomal breaks at multiple locations and involves impaired DNA repair.

Genome Instability in Tumors - German Cancer Research Center

Chromothripsis is frequent in cancer and linked with poor prognosis in a number of tumour types. The research in our group aims at achieving a better ...

Concurrence of chromosome 6 chromothripsis and glioblastoma ...

Analysis of the 1000+ gliomas profiled by The Cancer Genome Atlas (TCGA) data set revealed one case of chromosome 6 chromothripsis resembling ...

Martin Hetzer -Chromothripsis and Genome Instability in Cancer

An error occurred, please try again later. Try again. Martin Hetzer -Chromothripsis and Genome Instability in Cancer. Details. Back. No description provided.

Chromothripsis in Treatment Resistance in Multiple Myeloma

Many studies have shown an association of chromothripsis with the prognosis in several cancers; however, few studies have investigated it in MM.

Research - Peter Ly Lab

This is epitomized by chromothripsis – large-scale genome rearrangements caused by the catastrophic shattering of an entire chromosome followed by its haphazard ...

Chromothripsis: A New Frontier in Cancer Research

Chromothripsis: A New Frontier in Cancer Research ... Chromothripsis is a process where a single catastrophic event shatters a chromosomal region, ...