Chromothripsis in cancer

Comprehensive analysis of chromothripsis in 2,658 human cancers ...

Chromothripsis is a mutational phenomenon characterized by massive, clustered genomic rearrangements that occurs in cancer and other ...

Chromothripsis and cancer: causes and consequences of ... - Nature

Chromothripsis is an emerging phenomenon that results in chromosome rearrangements in tumour cells. This Review discusses the possible ...

Chromothripsis—Explosion in Genetic Science - PMC

Chromothripsis is regularly found in blood cancer, cancer of the central nervous system, in soft tissue tumors and carcinomas [49,50], in osteosarcoma and ...

Comprehensive analysis of chromothripsis in 2,658 human cancers ...

A hallmark of chromothripsis is multiple oscillations between two or three copy-number (CN) states. Applying this criterion to CN profiles inferred from SNP ...

Chromothripsis, DNA repair and checkpoints defects - ScienceDirect

Chromothripsis plays a major role in cancer as well as in other conditions, such as congenital diseases. In this review, we discuss the repair processes ...

Pan-cancer analysis of chromothripsis-related gene expression ...

In this study, we found that the transcriptional profile of five tumor types experiencing chromothripsis is associated with an immune evasion phenotype.

Chromothripsis - an overview | ScienceDirect Topics

Chromothripsis is another type of chromosome alteration observed in pancreatic cancer. It is a catastrophic event that occurs during mitosis and possesses the ...

Chromothripsis Explorer - Park Lab

In polyploid tumors we inferred whether canonical chromothripsis events occurred before or after polyploidization. For example, if the CN oscillation occurs ...

Chromothripsis - Wikipedia

Chromothripsis is a mutational process by which up to thousands of clustered chromosomal rearrangements occur in a single event in localised and confined ...

Massive Genomic Rearrangement Acquired in a Single Catastrophic ...

The stamp of chromothripsis can be seen in at least 2%–3% of all cancers, across many subtypes, and is present in ∼25% of bone cancers. We find that one, or ...

Chromothripsis and Focal Copy Number Alterations Determine Poor ...

Chromothripsis occurs in approximately 2% to 3% of all cancers, yet more frequently in osteosarcoma and chordoma (up to 25%), whereas malignant melanoma is ...

Chromothripsis-like patterns are recurring but heterogeneously ...

Recently, using state-of-the-art genome analysis techniques, a phenomenon termed “chromothripsis” was characterized in cancer genomes, defined ...

Chromothripsis is a common mechanism driving ... - Genome Biology

Structural rearrangements form a major class of somatic variation in cancer genomes. Local chromosome shattering, termed chromothripsis, ...

Chromothripsis in human cancer - EMBL-EBI

Chromothripsis in human cancer. Artists impression of chromothripsis. Artists impression of chromothripsis. Image credit: Spencer Phillips.

Chromothripsis: A New Frontier in Cancer Research

Chromothripsis: A New Frontier in Cancer Research ... Chromothripsis is a process where a single catastrophic event shatters a chromosomal region, ...

Chromothripsis: Current Biology - Cell Press

Currently, chromothripsis has been identified in cancer cells and in the male germline. Figure 1. When a chromosome missegregates during ...

Comprehensive analysis of chromothripsis in 2,658 human cancers ...

Chromothripsis is a newly discovered mutational phenomenon involving massive, clustered genomic rearrangements that occurs in cancer and other ...

Chromothripsis in human cancer | EMBL

Chromothripsis, or 'chromosome shattering', is a mutational process in which large stretches of a chromosome undergo massive rearrangements in a single ...

Chromosomal Rearrangements and Chromothripsis: The Alternative ...

Indeed, chromothripsis has been linked to tumor initiation and progression in many tumor ... chromothripsis in cancer genomes. Cell 2013, 152, ...

Cell‐based model systems for genome instability: Dissecting the ...

Chromothripsis, originally discovered in cancer genomes, constitutes a new class of massive genomic rearrangements, which is characterized by ...