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In Vitro Generated Intervertebral Discs


Collagen-Derived N-Acetylated Proline-Glycine ... - Oxford Academic

In this study, we found that N-Ac-PGP generated during intervertebral disc degeneration (IDD) is a factor that induces the migration Cartilage Endplate Stem ...

Tissue-engineered intervertebral discs produce new matrix ... - PNAS

Engineered IVD Integrated with Neighboring Vertebrae and Produced Extracellular Matrix with Native Levels of Collagen and Proteoglycan in the AF and NP. It was ...

Cell-based Regeneration of Intervertebral Disc Defects - CORE

The ECM produced by the NP cells is rich in proteoglycans (PGs), predominantly aggrecan and type-II collagen, whereas the AF cells produce a matrix which is ...

in vitro studies of human disc cell gene expression and matrix produc

쑖 2004 Elsevier Inc. All rights reserved. Keywords: Intervertebral disc; Tissue engineering; Tissue culture; Disc cells; Collagen; Proteoglycan; ...

Human-induced pluripotent stem cells generated from intervertebral ...

We investigated the pluripotency of disc cell-derived iPSCs (diPSCs) and neural differentiation capability as well as therapeutic effect in spinal cord injury.

Accelerated cellular senescence in degenerate intervertebral discs

Senescence biomarkers in human intervertebral disc cells in vitro ... discs, corroborating the recent data produced by Gruber and colleagues [13].

Intervertebral disc regeneration: do nutrients lead the way?

In this Perspectives article, we discuss whether the limited nutrient supply to degenerate discs might adversely affect various biological ...

Degeneration and regeneration of the intervertebral disc

The regenerative capacity of the notochordal cell: tissue constructs generated in vitro under hypoxic conditions . J. Neurosurg. Spine. 10.

An In Vitro Assessment Of Wear Particulate Generated From NUBAC ...

Spinal Day Surgery Specialists Lumbar Fusion, Disc replacement, Spinal Decompression Surgery, Kyphoplasty, Laser Spine Surgery and more ... Please note : These ...

‪Hiromichi Fujie‬ - ‪Google Scholar‬

Intervertebral disc regeneration with an adipose mesenchymal stem cell-derived tissue-engineered construct in a rat nucleotomy model. H Ishiguro, T Kaito, S ...

Cartilage - Wikipedia

... intervertebral discs. In other taxa, such as chondrichthyans and cyclostomes, it constitutes a much greater proportion of the skeleton. It is not as ...

Tissue-engineered intervertebral disc with living cells - Google Patents

The present invention relates to a tissue-engineered intervertebral disc (IVD) comprising a nucleus pulposus structure comprising a first population of ...

Biomaterials Science Blog

Injectable biomaterial induces regeneration of the intervertebral disc in a caprine loaded disc culture model. Joseph W. Snuggs, Kaj S ...

Intervertebral Disc Tissue Engineering - Bonassar Lab

Motivation. The primary cause of lower back pain in the US is intervertebral disc (IVD) degeneration, leading to an annual healthcare cost burden of $90 ...

Watch these tissue engineered spinal discs mimic the real thing

Goats and rats respond well to implants—lab-grown tissue may one day replace discs in people.