Mechanisms and Management of Immune Checkpoint Inhibitor ...

Immune checkpoint inhibitors in malignancy - Australian Prescriber

Immune checkpoint inhibitors have already become the first-line treatment for patients with advanced melanoma and non-small cell lung cancer.

Focus on Immune Checkpoint Inhibitors-related Intestinal Inflammation

Immune checkpoint inhibitors are promising new cancer immunotherapies that have seen a breakthrough recently for the treatment of several cancer ...

Cardiotoxicity in cancer immune-checkpoint therapy

Immune-checkpoint inhibitors (ICIs), a unique antibody-based therapeutic strategy, have revolutionized the treatment landscape of solid and ...

Managing Resistance to Immune Checkpoint Inhibitors in Lung ...

To date, several combination therapies are under development to delay or prevent the occurrence of resistance to ICIs, including the blockade of ...

Clinical spectrum and evolution of immune-checkpoint inhibitors ...

Immune-checkpoint inhibitors (ICI) have revolutionized cancer treatment by harnessing the immune system but ICI can induce life-threatening immune-related ...

Management of pulmonary toxicity associated with immune ...

Besides their efficacy, these agents also generate specific immune-related adverse events. Due to the increasing prescription of immune-checkpoint inhibitors, ...

Identification of shared mechanisms and targets between immune ...

Use of immune checkpoint inhibitors in the treatment of patients with cancer and preexisting autoimmune disease: a systematic review. Ann Intern Med 2018; 168(2): ...

Hallmarks of response, resistance, and toxicity to immune ...

The genetic status of the tumor is one of the primary determinants of response to treatment with immune checkpoint inhibitors (Figure 2). Over ...

Study Results Find Different Mechanisms of Action in 2 Immune ...

Study Results Find Different Mechanisms of Action in 2 Immune Checkpoint Inhibitor Regimens ... The differences between the regimens, anti-PD1/ ...

The mechanism and risk factors for immune checkpoint inhibitor ...

Immune checkpoint inhibitors (ICIs) are promising new immunotherapeutic drugs that reactivate T cells to kill tumor cells by the blocking ...

Management of toxicities from immunotherapy: ESMO Clinical ...

Adverse events (AEs) related to the use of immune checkpoint inhibitor (ICI) therapy are defined as immune-related (IR) AEs (irAEs).

Characterizing Mechanisms of Response and Resistance to ...

Full Title: Characterizing Mechanisms of Response and Resistance to Immune Checkpoint Inhibitor Therapy Using Cell Subpopulation Gene ...

Myocarditis Induced by Immune Checkpoint Inhibitors: Mechanisms ...

The PD-1/PD-L1 signalling pathway is particularly important for limiting the ability of T cells to attack the heart. Immune checkpoint ...

Mechanisms of resistance to immune checkpoint inhibitors

Immune checkpoint inhibitors (ICI) targeting CTLA-4 and the PD-1/PD-L1 axis have shown unprecedented clinical activity in several types of cancer and are ...

Immune checkpoint inhibitor–associated myocarditis - JCI

Immune checkpoint inhibitors (ICIs) have transformed the treatment of various cancers, including malignancies once considered untreatable.

Integrating immune checkpoint inhibitors and targeted therapies in ...

In the metastatic setting, tyrosine kinase inhibitors (TKIs) for oncogene-addicted tumours and immune checkpoint inhibitors (ICIs) have revolutionised the ...

Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical ...

Here, we review the history and clinical utility of ICIs, the mechanisms of resistance to therapy, and local and systemic immune cell changes ...

Concurrent immune checkpoint inhibition and selective ...

Purpose Immune checkpoint inhibitor (ICI) therapy is often suspended because of immune-related enterocolitis (irEC). We examined the effect of resumption of ...

LAG-3 inhibitors: A new type of immunotherapy

Immunotherapy harnesses the natural power of the immune system and enhances its response to cancer. Immune checkpoint inhibitors are the most ...

Cardiovascular Toxicities of Immune Checkpoint Inhibitors

Immunotherapy, with its usefulness in the treatment of previously minimally responsive cancers, has been at the forefront of this revolution. Immune checkpoint ...