New vascular insights into premature aging

Peer review in Direct reprogramming of human smooth muscle and ...

This is a novel and exciting proposed approach to study mechanisms of age-related vascular dysfunction and may provide actionable in vitro ...

Vascular Risk Factors and Brain Health in Aging - Sage Journals

The aging population and high rates of Alzheimer's disease (AD) create significant medical burdens, prompting a need for early prevention.

Impact of aging on vascular ion channels: perspectives and ...

Individuals aged ≥65 yr will comprise ∼20% of the global population by 2030. Cardiovascular disease remains the leading cause of death in ...

Vascular smooth muscle cell aging: Insights from Hutchinson-Gilford ...

Gerhard-Herman, Mechanisms of premature vascular aging in children with ... Osorio, Splicing-directed therapy in a new mouse model of human accelerated aging, Sci ...

Dr Yolandi Breet Unveils Insights on Arterial Stiffness and ... - YouTube

Dr Yolandi Breet Unveils Insights on Arterial Stiffness and Early Vascular Aging ... New 81 views · 1:30. Go to channel · Prof Marlien Pieters ...

insights from studies on cellular senescence, stem cell aging ... - Gale

As discussed, the features of premature aging (including cardiovascular changes) in patients with progeroid syndromes are markedly different to those of normal ...

New insights into RhoA/Rho-kinase signaling: a key regulator of ...

A recent study showed that murine arteries have a more abundant expression of Gαq/11 proteins within vascular SMCs, as well as endothelial cells during ageing.

A-type lamins and cardiovascular disease in premature aging ...

Here, we review studies in cell and mouse models and patients that are unraveling how abnormal prelamin A and progerin accumulation accelerates cardiovascular ...

Vascular aging: Insights from studies on cellular senescence, stem ...

Such impairment could be attributable to senescence of cardiovascular tissues at the cellular level as a result of telomere shortening, DNA damage, and genomic ...

Cells | Special Issue : Advances in Vascular Aging - MDPI

Researchers could present novel findings on the role of oxidative stress, inflammation, and genetic factors in accelerating vascular aging. Insights into ...

Concept of Extremes in Vascular Aging Brief Review

With advancing age, changes in the arterial wall con- tribute to what has been called vascular aging, and in some prematurely affected ...

Vascular smooth muscle cell loss underpins the accelerated ...

Mutations in LMNA have been linked to premature aging disorders, including. Hutchinson-Gilford progeria syndrome (HGPS). HGPS is caused by progerin, an aberrant ...

Organ-on-a-chip model offers insights into premature aging ... - Bionity

HGPS primarily affects vascular cells, which undergo biomechanical strains in blood vessels. However, the impact of these biomechanical strains ...

Researchers identify molecule with anti-aging effects on vascular ...

This compound can delay vascular aging through endothelial cells, which line the interior surface of blood vessels and lymphatic vessels. It can ...

Aging-related mutations in blood cells represent major new risk factor for cardiovascular disease ... Scientists at the Broad Institute of MIT and ...

Innovations in Atherosclerosis Have Potential to Benefit Patients ...

New discoveries in atherosclerosis pathways have shed light on the active mechanisms in other diseases such as chronic kidney disease (CKD) ...

Implications of Early Vascular Aging in Patients With Chronic Kidney ...

New research being presented at the American Heart Association (AHA) ... Transforming Oncology Care: Insights into NCODA's PQI Initiatives.

Molecular insights into vascular aging

Molecular insights into vascular aging · Kirsty Foote , Martin R. Bennett , · Received: November 27, 2018 Published: December 5, 2018.

Global Burden of Disease (GBD)

health outcomes and risk factors provide a powerful basis for insights on global health trends and challenges. 204 countries and territories, plus dozens of ...

Vascular Risk Factors and Brain Health in Aging - Sage Journals

Karran E, De Strooper B (2022) The amyloid hypothesis in Alzheimer disease: New insights from new therapeutics, Nat Rev Drug Discov 21, 306–318. Crossref.