Noncoding RNAs and RNA Editing in Brain Development ...

Manipulation of Long Non-coding RNAs in Cardiovascular Disease ...

The traditional view on non-coding RNA (ncRNA) as “junk of the genome” has been revolutionized to how we view eukaryotic genome complexity.

Adenosine-to-inosine RNA editing shapes transcriptome diversity in ...

We found that, on average, the editing level in the transcripts analyzed is higher in human brain compared with nonhuman primates, even where the genomic Alu ...

Mount Sinai Study Reveals Significant Differences in RNA Editing ...

These sites are known to be involved in neuronal maturation and brain development. Aberrant regulation of A-to-I editing has been linked to ...

RNA-targeting CRISPR reveals that hundreds of noncoding RNAs ...

Most CRISPR applications use an enzyme called Cas9 to edit genes on the DNA level. However, a newer technology uses the enzyme Cas13 to more ...

Whole-transcriptome RNA editing analysis in single cortical neurons ...

Putative editing sites were intersected with sites in bulk human tissue transcriptomes including healthy and neuropsychiatric brain tissue, and ...

CRISPR Study Reveals Unexpected Roles of Non-Coding RNAs

“This was a big surprise,” said Lim, whose lab has been studying the role of lncRNAs in brain development. “Typically, protein-coding genes ...

Comprehensive Identification of Long Non-coding RNAs in Purified ...

Our results demonstrated the role of lncRNA in the context of oligodendrocyte cell fate determination, and provided an extensive resource and a powerful ...

Study provides more nuanced insights into RNA modifications by A ...

This broad sweep enabled researchers to develop a model depicting for the first time how A-to-I editing evolves over a lifetime, in which ...

Non-coding RNA (ncRNA) (video) - Khan Academy

Non-coding RNAs (ncRNAs) are functional RNA molecules that don't translate into proteins. They play vital roles in cellular processes, including transcription ...

RNA | Definition, Structure, Types, & Functions - Britannica

A class of RNAs containing repeat sequences is known to sequester RNA-binding proteins (RBPs), resulting in the formation of foci or aggregates in neural ...

Non-coding RNAs and Epigenetics - YouTube

Click "Show More" to see the full schedule of speakers and links to individual talks. Each month, Life Science Across the Globe highlights ...

‪Mark F. Mehler‬ - ‪Google Scholar‬

Developmental biology 367 (2), 100-113, 2012. 341, 2012. Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological ...

The Noncoding Regulators of the Brain | TS Digest - The Scientist

Of course, noncoding RNAs aren't solely expressed during brain development. In addition to steering neurogenesis, “RNA transactions are critical ...

RNA-edited regions in brain shed light on neurodevelopment and ...

The scientists described how the rate of RNA editing in the brain rises with age in a study that was published in Cell Reports. This finding has ...

‪Tetsuro Hirose‬ - ‪Google 学术搜索‬ - Google Scholar

... Noncoding RNA. ... MENε/β noncoding RNAs are essential for ... editing of chloroplast mRNAs: development of a chloroplast in vitro RNA editing system.

Long non-coding RNAs in Development & Disease Progression

Long noncoding RNAs (LncRNAs) are eukaryotic RNA molecules greater than 200 nucleotides in length that have no protein-coding capacity.

Evo: DNA foundation modeling from molecular to genome scale

... RNA, and proteins. It is capable of both ... Evo performs zero-shot function prediction for proteins, non-coding RNAs, and regulatory DNA.

Genomics - Wikipedia

Genomics is an interdisciplinary field of molecular biology focusing on the structure, function, evolution, mapping, and editing of genomes.

Dynamic regulation of RNA editing in human brain development and ...

RNA editing is increasingly recognized as a molecular mechanism regulating RNA activity and recoding proteins. Here, I surveyed the global landscape of RNA ...

Gene therapy investment struggles: What's driving the slowdown?

It also partnered with RNA-focused Genevant Sciences in a $114 million deal to develop a gene editing treatment for a rare liver disorder.