Structure and Function of the calcium|selective TRP channel TRPV6

Transient Receptor Potential (TRP) Channels and Calcium Signaling

Exploring structure-function relationships between TRP and Kv channels. ... Crystal structure of the epithelial calcium channel TRPV6. Nature 534: 506 ...

TRPV Channels and their Pharmacological Modulation

In contrast to the polyselective TRPV channels TRPV5 and TRPV6 show strong inward rectification due to voltage-dependent intracellular Mg2+-block at positive ...

Cryo-EM structure of human TRPV6 in complex with channel blocker

Title: Structural mechanisms of TRPV6 inhibition by ruthenium red and econazole. ... Abstract: TRPV6 is a calcium-selective ion channel implicated in epithelial ...

Transient Receptor Potential Channels and Calcium Signaling

In this review, we summarize and discuss recent insights into the role of TRP channels in cellular Ca2+ signaling, with particular focus on the structural ...

Cryo-electron microscopy structure of the TRPV2 ion channel

Description: Epithelial calcium channel TRPV6 is a member of the vanilloid subfamily of TRP channels that is permeable to cations and highly ...

Structural insight into TRPV5 channel function and modulation - PNAS

Transient receptor potential vanilloid 5 (TRPV5) and its close homolog TRPV6 are unique among all TRP channels because of their high selectivity ...

Structure-based characterization of novel TRPV5 inhibitors - eLife

Transient receptor potential vanilloid 5 (TRPV5) is a highly calcium selective ion channel that acts as the rate-limiting step of calcium ...

TRP channels at a glance | Journal of Cell Science

TRPV5 and TRPV6 are thought to be involved in the re-absorption of calcium in the renal tubules and intestine (den Dekker et al., 2003). In ...

Structural insight into TRPV5 channel function and modulation

TRPV5 (transient receptor potential vanilloid) is a unique calcium-selective TRP channel that is essential for calcium homeostasis. TRPV5 and ...

Inactivation-mimicking block of the epithelial calcium channel TRPV6

Sobolevsky, Structure and function of the calcium-selective TRP channel TRPV6. J. Physiol., https://doi.org/10.1113/ · JP279024 (2020). 4 ...

The Structural Basis of Calcium-Dependent Inactivation of the ...

The transient receptor potential vanilloid channel subfamily member 5 (TRPV5) is a highly selective calcium ion channel predominately ...

Activity of the yeast vacuolar TRP channel TRPY1 is inhibited by Ca 2+

... TRPV6–CaM channel structures ... structure-function relationships conserved among different subfamilies of transient receptor potential channels.

TRPV5 in renal tubular calcium handling and its potential relevance ...

The recently resolved high-resolution structure of the epithelial Ca2+ channel transient receptor potential vanilloid 5 (TRPV5) increased our ...

Citations to Renal Ca2+ wasting, hyperabsorption, and ... - JCI

Structure and function of the calcium‐selective TRP channel TRPV6 MV Yelshanskaya, KD Nadezhdin, MG Kurnikova, AI Sobolevsky, The Journal of Physiology, 2020.

EMDB-7824: Cryo-EM structure of human TRPV6-Y467A in amphipols

The TRP channel TRPV6 mediates calcium uptake in epithelia and its ...

Transient receptor potential channel - Wikipedia

Mammalian TRP channels are activated and regulated by a wide variety of stimuli and are expressed throughout the body.

5IWK: Structure of Transient Receptor Potential (TRP) channel TRPV6

Precise regulation of calcium homeostasis is essential for many physiological functions. The Ca(2+)-selective transient receptor potential ...