The Primary Outcome Fails

The Primary Outcome Fails — What Next?

Vatiquinone Fails to Meet Primary Endpoint But Has Benefits in FA

PTC Therapeutics announces that the MOVE-FA vatiquinone trial fails to meet primary endpoint but shows benefits in Friedreich ataxia.

ACTRIMS 2024: Tolebrutinib fails to eliminate PRLs in small study

Gaitán's late-breaking presentation was titled, “Primary Outcome of ... Four patients then moved to a 120 mg daily dose for the next 48 weeks, ...

Interpreting clinical trial results: is a positive primary outcome good ...

4. Are secondary outcomes supportive? Positive, pre-specified secondary outcomes can improve confidence in the overall “positivity” of a trial, ...

Phase 3 REBUILD Trial Fails To Meet Primary Endpoint - Nasdaq

"The REBUILD study did not match the outcomes we saw in the exploratory Phase 2 study in this patient population; however, the overall outcome ...

ImmunoGen Announces Top-Line Results from Phase 3 FORWARD ...

ImmunoGen is developing the next generation of antibody-drug conjugates (ADCs) to improve outcomes for cancer patients. By generating targeted ...

Tamibarotene Plus Azacitidine Fails to Improve CR Rates in High ...

“We plan to stop the study, review the clinical data more thoroughly, and evaluate the next steps. We want to express our sincere appreciation ...

Frequently Asked Questions | National Archives

If the President-elect fails to qualify before inauguration, Section 3 of the 20th Amendment states that the Vice President-elect will act as President until ...

2023's top 10 clinical trial flops - Fierce Biotech

Once again, we're taking our annual look at the biggest clinical trial failures of the year. The ones that made our eyes pop as we checked those ...

Syros Stock Plunges as Lead Cancer Study Fails to Meet Primary Goal

SYRS stock plummets as late-stage cancer study of lead candidate fails to achieve its primary endpoint leading to the termination of the ...

1 in 10 FDA-Approved Drugs Miss Primary End Point in Pivotal Trial

... primary endpoint was null based on findings. 1 The new data—which ... The team then characterized the FDA's expressed rational included ...

Global Climate Agreements: Successes and Failures

The findings of the first global stocktake, discussed at the 2023 UN Climate Summit in Dubai, United Arab Emirates (UAE), concluded that governments need to do ...

Results - City of San Francisco

View past election results. 2024. November 5, 2024, Consolidated General Election · March 5, 2024, Presidential Primary Election ...

MARINER Fails to Meet Primary Endpoint Testing Rivaroxaban for ...

Any hints of benefit on secondary endpoints are hypothesis-generating and need to be confirmed prospectively in separate trials.

Clinical trials are the gold standard for informing clinical practice ...

Changing these endpoints is something that researchers occasionally have to do during a clinical trial in order to be able report results. This ...

Ferrer's ALS Agent FAB122 Fails to Meet Primary, Secondary End ...

Ferrer, despite acknowledging the unfavorable outcome, remains ... “We will continue to do our utmost to find a treatment for ALS as soon as ...

Mirror, Mirror 2024: A Portrait of the Failing U.S. Health System

Since then, however, the U.S. has far outpaced other nations, spending more than 16 percent of its GDP on health care in 2022 (Exhibit 3). That ...

win ratio: a new approach to the analysis of composite endpoints in ...

Consider a primary composite endpoint, e.g. cardiovascular (CV) death and heart failure hospitalization (HF hosp) in heart failure trials. For ...

ATTRACT fails to meet primary endpoint, but experts agree results ...

... next phase of deep vein thrombosis research,” he said. TAGS; ATTRACT · catheter-directed thrombolysis · Deep vein thrombosis · DVT · headline ...

What are primary vs. secondary outcomes? - | Evidence for Action

At least one of the primary outcomes must be a novel or meaningful outcome related to health or racial equity. Secondary outcomes are those more exploratory in ...

Chapter 12: Synthesizing and presenting findings using other methods

... the primary studies. Alternative synthesis methods differ in ... then the decision rules were applied to select the most relevant outcome for synthesis.