The genomic landscape of pediatric and young adult T|lineage ...

Studies Describe New Alterations in Pediatric T-Cell ALL

... children or young adults enrolled in a COG trial between 2007 and 2011. Those data — coupled with whole genome sequences for 25 of the cases ...

First large-scale genomic analysis of key acute leukemia will likely ...

Charting the genomic landscape of T-lineage ... The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia.

Genomic and outcome analysis of adult T-cell lymphoblastic ...

in children and young adults.1 T-LBL is characterized by a ... The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia.

Comprehensive Genomic Profiling of 282 Pediatric Low‐ and High ...

... T mutations, a genomic signature that better aligns with an astrocytic lineage glioma. ... the genomic landscape. Surprisingly, in our pHGG ... adult and pediatric ...

Childhood Cancer Genomics (PDQ®): Treatment

Liu Y, Easton J, Shao Y, et al.: The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia. Nat Genet 49 (8): ...

Translating genomic discoveries to the clinic in pediatric oncology

Outcome for children and young people with early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL. Br J Haematol ...

A Retrospective Genomic Landscape of 661 Young Adult ...

Comparisons of frequently altered genes in our young adult glioblastoma cohort with pediatric glioblastomas revealed striking differ- ences ...

Genomics and precision medicine in pediatric acute lymphoblastic ...

Outcome for children and young people with Early T-cell ... The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia.

Genomic Landscape of Large Granular Lymphocyte Leukemia

Finally, we conducted a comprehensive analysis of pediatric and young adult LGL leukemia patients in 23 young adult (age <30), 105 adult (age 30-50), and 89 ...

Immuno-genomic landscape of osteosarcoma - EGA European ...

Immuno-genomic landscape of osteosarcoma. Osteosarcoma is an orphan disease affecting children and young adults ... genome, transcriptome, T-cell receptor ...

The Somatic Genomic Landscape of Glioblastoma - Cell Press

reported that adult and pediatric GBM with alterations of IDH1, H3F3A, and receptor tyrosine kinases (RTK) were associated with epigenetic subtypes (Sturm et al ...

Genetic mutational analysis of pediatric acute lymphoblastic ...

The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia. Nat Genet. 2017;49:1211–8. Article CAS PubMed ...

Novel Insights May Transform Diagnosis and Treatment of Pediatric ...

Pediatric, adolescent, and young adult patients with T-lineage ALL typically respond well to initial treatment. However, those who relapse ...

The Clinico-Genomic Landscape of Induction Failure in Childhood ...

The Clinico-Genomic Landscape of Induction Failure in Childhood and Young Adult T-Cell Acute Lymphoblastic Leukemia (T-ALL) | Bl… https ...

Genetic and Epigenetic Targeting Therapy for Pediatric Acute ...

The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia. Nat. Genet. 2017, 49, 1211–1218. [Google Scholar] [CrossRef] ...

The genomic basis of childhood T-lineage acute lymphoblastic ...

The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia. Nat Genet 49, 1211-1218 (2017). https://doi.org ...

Paper: The Genomic Landscape of Childhood T-Lineage Acute ...

Here we report sequencing of 264 T-ALL consecutive cases treated on the Children's Oncology Group AALL0434 clinical trial. Whole exome ...

The genomic landscape of pediatric Ewing sarcoma. | Broad Institute

SIGNIFICANCE: We performed next-generation sequencing of Ewing sarcoma, a pediatric cancer involving bone, characterized by expression of EWS-ETS fusions. We ...

The evolving genomic landscape of acute lymphoblastic leukemia ...

Dr Mullighan also describes studies of larger cohorts of ALL patients across an age range from children to older adults, which gives us a ...

Optimizing Clinical Outcomes Through Multidisciplinary Collaboration

Evens highlighted a trend in the lymphoma landscape ... T-cell lymphomas––with the same problem to ... Treatment paradigms differ between adult and ...