The role of circadian gene CLOCK in cancer

The Circadian Clock Gene, Bmal1, Regulates Intestinal Stem Cell ...

Circadian rhythms are known to be important for health, but whether their loss contributes to colorectal cancer is not known. We tested the ...

Circadian Rhythms in Anticancer Immunity - Annual Reviews

38. Lee Y. 2021.. Roles of circadian clocks in cancer pathogenesis and treatment. ... Pharmacological modulation and genetic deletion of REV-ERBα ...

UC Irvine study reveals circadian clock can be leveraged to ...

“Understanding precisely how circadian disruption promotes disease progression could lead to behavior modification to reduce cancer risk.” Team ...

Ras-Mediated Deregulation of the Circadian Clock in Cancer - PLOS

Circadian rhythms are essential to the temporal regulation of molecular processes in living systems and as such to life itself. Deregulation of these ...

Pathophysiologic Role of Disrupted Circadian and Neuroendocrine ...

Several mechanisms have been proposed by which shift work-induced circadian disruption promotes cancer. In this review, we examine the importance of the brain- ...

Study shows how liver cancer hijacks circadian clock machinery ...

For example, Kay and his team hope to explore the relationship between circadian clock proteins, Wee1, and the P53 gene. The gene helps prevent ...

Disrupting the circadian clock: Gene-specific effects on aging ...

Some circadian clock genes have been described as tumor suppressors, while other genes have less clear functions in aging and cancer. In this ...

Circadian clock features define novel breast cancer subtypes and ...

The circadian clock regulates key physiological processes, including cellular responses to DNA damage. Circadian-based therapeutic strategies ...

The Time of Our Lives - Learn Genetics (Utah)

Clock genes may some day help scientists treat cancer. At least eight clock genes are known to coordinate normal functions such as cell proliferation (which is ...

The surprising link between circadian disruption and cancer may ...

Disruptions in circadian rhythm—the ways that our bodies change in response to the 24-hour light and dark cycle—have been linked to many ...

Study reveals liver-brain communication as key to managing ...

The suprachiasmatic nucleus (SCN) serves as the master circadian clock, using light cues to establish feedback loops (TTFLs) of molecular-clock ...

What Role Do Circadian Genes Play in Cancer?

Circadian genes are integral in maintaining the body's internal clock and can influence cancer pathways. Genes like PER, CLOCK, and BMAL1 are known to play.

Joseph Takahashi (UT Southwestern/HHMI) Part 1A: Circadian Clocks

https://www.ibiology.org/genetics-and-gene-regulation/circadian-clocks/ Lecture Overview: Circadian rhythms are an adaptation to the 24 hr ...

Rhythmic liver drives feeding behavior | Science

Deletion of the core clock components REV-ERBα and REV-ERBβ in adult mouse hepatocytes disrupts circadian changes in gene expression and liver ...

Unlocking the Secrets of Our Circadian Rhythms - YouTube

... clock molecules such as CLOCK, BMAL1, and the PER and CRY proteins in our cells, investigating their roles in the regulation of circadian ...

Circadian time-keeping in the brain - Michael Hastings - YouTube

... Molecular Biology. Michael Hastings' group aims to provide a molecular genetic explanation for the ancient conserved process of circadian timing ...

How gut bacteria regulate stress and sleep cycles - News-Medical

These findings highlight the integrated role of gut microbiota in regulating both the circadian rhythm and stress response, with potential ...

Disrupted Eating Cycles? Liver-Brain Signals Hold Key to Balance

Researchers specifically targeted genes called REV-ERBs in the liver cells of mice. REV-ERBs are important proteins that help regulate the ...

Bench to Bedside: Genetics of Circadian Rhythms, Part 1 - YouTube

... Circadian Clocks: Clock Genes, Cells and Circuits. Science ... Cancer Worse!" The Diary Of A CEO•3.7M views.

Clock-Controlled Genes Part 1: Transcriptional regulation - YouTube

An introductory tutorial video on how the mammalian molecular circadian clock is regulated, and regulates other genes.