Understanding and targeting resistance mechanisms in cancer

The role of molecular heterogeneity targeting resistance ...

The role of molecular heterogeneity targeting resistance mechanisms to lung cancer therapies ... Deeper understanding of heterogeneity determinants and the ...

Promising cancer therapies target DNA circles | Stanford Report

“We're in the midst of a completely new understanding of a common and aggressive mechanism that drives cancer,” said Mischel, who holds the ...

DNA Damage Response - AstraZeneca

Understanding DDR pathways and the proteins involved allows us to target tumour-specific DDR dependencies to preferentially kill cancer cells. Normal ...

Studying Drug Resistance in Cancer - YouTube

Gad Getz, PhD is a Professor of Pathology at Harvard Medical School. He is also on the faculty and Director of Bioinformatics at the ...

5O Deciphering resistance mechanisms in cancer - ESMO Open

Background: Understanding the resistence mechanisms of tumor is crucial for ... target resistance and. 24.9% (54/217) exhibited a by-pass resistance ...

Novel Combos Target Resistance Mechanisms in Advanced ...

Acquired resistance to endocrine therapy has presented challenges for patients with hormone receptor–positive breast cancer.

Cracking the code of DNA circles in cancer, Stanford Medicine-led ...

Tiny circles called ecDNA are critical in cancer development and drug resistance ... cancer therapy targeting the circles that is already in ...

Oral Fenbendazole for Cancer Therapy in Humans and Animals

Anti-cancer Mechanisms and Targets of Fenbendazole. Studies attribute ... tumors and targeting drug-resistant cancer cells through glycolysis inhibition.

Pharmacokinetics, Clinical Indications, and Resistance Mechanisms ...

The strategy for discovery and development of new cancer drugs has shifted the field from cytotoxic agents to therapies that selectively target ...

European Society for Medical Oncology

ESMO is the European Society for Medical Oncology, providing a professional network for its members and working with national societies across Europe.

DLL4-targeted CAR-T therapy sensitizes neoadjuvant ...

The mechanism of THP therapy resistance and how to reverse it remain to be elusive. WHAT THIS STUDY ADDS. Delta-like ligand 4 (DLL4)+ tumor cells displayed ...

To target, to escape, perchance to cure: Borrowing a page ... - Science

Small-molecule inhibitors block specific molecular pathways relevant for tumor biology. Other therapies exploit the immune system, which has ...

Scientists map cancer mutations in EGFR gene, revealing drug ...

... tumor growth and mechanisms of drug resistance. Background. Despite advances in genome sequencing, several genetic variants remain classified ...

Targeting Cancer Pathways: Understanding Immune Checkpoints

Comments11 · Targeting Cancer Pathways: Tumor Resistance · Deciphering Immuno-Oncology: Targeting Cellular Mechanisms of the Tumor Immune Response.

EGFR Inhibitors Extend Their Reach in Lung Cancer | Blog | AACR

Since MET activation is one way cancer cells circumvent EGFR inhibition, the combined block is meant to delay or prevent treatment resistance.

Breakthrough research reveals how to target malignant DNA in ...

Many of the most aggressive cancers depend on ecDNA for survival, and as these cancers advance, ecDNA drives their resistance to treatment, ...

9 biotech companies advancing treatment for breast cancer in 2024

The company focuses on targeting key mechanisms that drive aggressive and resistant forms of cancer. ... understand that my personal data ...

Targeting carbohydrate metabolism in colorectal cancer - Oncoscience

This approach would offer a more comprehensive understanding of the events occurring in cancer cells following cisplatin treatment. Moreover, when we added ISS ...

Finding a way to harness evolution - Harvard Gazette

... cancer treatments often target but frequently fail because the diseased cells mutate resistance mechanisms. ... understand how changes in a ...

SITC 2024 Annual Meeting Schedule

... targeted CAR T cell to overcome a pan-tumor escape mechanism for solid tumors ... understand and review the mechanisms by which bugs can become new cancer drugs.