Validation of the Surrogate Threshold Effect for Change ...

Time to review the role of surrogate endpoints in health policy - CORE

Surrogate threshold effect: an alternative measure for meta-analytic surrogate endpoint validation. ... treatment-induced changes on the surrogate (i.e. ...

Validity of Surrogate Endpoints and Their Impact on Coverage ... - IRIS

change in estimated glomerular filtration rate (eGFR) in ... Surrogate threshold effect: an alternative measure for meta-analytic surrogate endpoint validation.

VALIDATION OF SURROGATE ENDPOINTS IN ADVANCED SOLID ...

It is, therefore, essential that candidate surrogate endpoints be properly validated. However, there is no consensus on statistical methods for such validation ...

Executive Summary 1.1 - Surrogate endpoints in oncology - IQWiG

PEP: patient-relevant endpoint; STE: surrogate threshold effect. Figure A: Impact (of the reliability of validation studies and the ...

Development of a framework and decision tool for the evaluation of ...

... change in surrogate and outcome undertaken in the ... Surrogate threshold effect: An alternative measure for meta-analytic surrogate endpoint validation.

How to use frailtypack for validating failure-time surrogate endpoints ...

We implemented the surrogate threshold effect which is used in combination with to make decisions concerning the validity of the surrogate ...

Validation of Exercise Capacity as a Surrogate Endpoint in Exercise ...

Spearman correlation coefficient (ρ), R2 at trial level, and surrogate threshold effect (STE) were calculated. STE represents the intercept of the prediction ...

Assessment of clinically relevant bleeding as a surrogate outcome ...

Ultimately, one would also need to know that a change ... Surrogate threshold effect: an alterna- tive measure for meta-analytic surrogate endpoint validation.

Metastasis-Free Survival Is a Strong Surrogate of Overall Survival in ...

Surrogate threshold effect (STE) is defined as the minimum treatment effect (HR) on the surrogate necessary to predict a nonzero treatment ...

Surrogate Endpoint | SpringerLink

Sometimes there are numerical problems when fitting these models. To apply the results to a new trial, the effect of treatment on surrogate ...

Informed decision‐making: Statistical methodology for surrogacy ...

of an observed trial-based change in the surrogate. ... Surrogate threshold effect: an alternative measure for meta-analytic surrogate endpoint validation.

Validation of 6-Minute Walk Distance as a Surrogate End Point in ...

We determined the threshold effect by calculating 95% prediction bands around the meta-regression line. The threshold was calculated as the ...

Information-theory based surrogate marker evaluation from several ...

Surrogate threshold effect: An alternative measure for meta-analytic surrogate endpoint validation. ... change your preferences before consenting. Please ...

SURROGATE ENDPOINTS IN ONCOLOGY - efspi

Trial-level R2: 0.61. 20. Page 21. The “Surrogate Threshold Effect” is the treatment effect ... • Treatment changes over time may affect the associations ...

an initial evaluation of a surrogate end point using a single ...

Consequently, current clinical research is focused on the development of surrogate end points, which shorten the time-span for their realization, while ...

Steps to Validation of Early Endpoints to Support Drug Development ...

The treatment has an effect on the surrogate. • The surrogate is associated with (or prognostic for) the true. (definitive) clinical outcome ...

Treatment-related changes ... Burzykowski, Surrogate threshold effect: an alternative measure for meta-analytic surrogate endpoint validation, Pharm Stat, № 5, с.

Validation of Surrogate Endpoints in Advanced Solid Tumors

... effects on the surrogate (i.e., the change on the ... Surrogate threshold effect: an alternative measure for meta-analytic surrogate endpoint validation.

Validity of Surrogate Endpoints and Their Impact on Coverage ...

change in estimated glomerular ... Surrogate threshold effect: an alternative measure for meta-analytic surrogate endpoint validation.