Drugging Undruggable Molecular Cancer Targets

Climbing the peaks of drug discovery – tackling the most ...

As a drug discovery scientist I think a lot about drug targets – which are the molecules in the cell, usually proteins, that drugs act on to ...

Innovative method unlocks potential for drugging undruggable ...

On a hunch, the team tested a dozen drugs that target K-Ras against a ... Tags: Breast Cancer, Cancer, Cell, CT, Drug Discovery, Drugs ...

“Protein sandwich” could transform cancer drug discovery

A breakthrough class of molecular glue identified at the University of Dundee could pave the way for a new generation of drugs to target cancers and ...

From Impossible to Inevitable: Transforming Undruggable Targets

In the dynamic world of drug discovery, the notion of "undruggable" targets ... molecule drugs. The Protein-Protein Interface Problem. PPIs are ...

Drugging an undruggable pocket on KRAS - PNAS

Although KRAS is an excellent drug discovery target for many cancers ... drugged with low molecular weight organic molecules. This belief ...

City of Hope scientists develop targeted chemotherapy able to kill all ...

... molecule AOH1996 targets a cancerous variant of the protein PCNA. ... drug that targeted only the form of PCNA in cancer cells. Our cancer ...

Synthetic lethality in lung cancer and translation to clinical therapies

Drug-drug interactions. Traditionally, drug combinations have been defined by simply combining two or more drugs with known single agent ...

Therapeutic targeting of “undruggable” MYC - The Lancet

This opens an exploitable window for treatment that makes MYC one of the most appealing therapeutic targets for cancer drug development.

'Drugging the undruggable' – another step towards blocking Ras

These types of drugs have previously been thought of as bad, he said. If a really sticky drug isn't selective for a cancer-causing molecule ...

New partnership will use molecular glues to tackle 'undruggable ...

... target with traditional drug discovery methods. These proteins will ... oncology targets that were previously considered undruggable using ...

Researchers target 'undruggable' cancers | University of Oxford

... Molecular Biology in Cambridge. Dr Andrew Turnbull, one of the ... drugs that target them and the proteins they control.' Professor ...

Scientists discover chemical probes for previously 'undruggable ...

"It's thought to lack the types of surfaces that small molecule drugs ... New insight into combating drug-resistant prostate cancer. Apr 10 ...

Molecular Targets Program | Center for Cancer Research

translates basic science advances into drug leads, bioprobes, and reagents for molecular target evaluation; ... The search for targeted drugs for cancer treatment ...

Molecular 'super-glue' shows promise of cancer drug discovery ...

Molecular 'super-glue' shows promise of cancer drug discovery platform ... target previously undruggable proteins. However, finding and ...

UAMS and Mayo Clinic Researchers Discover Key to Unlocking ...

Many cancer drugs target DNA binding proteins because they play essential roles in cancer cell development. Until now, these proteins generally ...

Molecular glues and induced proximity: solving the undruggable - CAS

... Drug discovery phase to develop small molecule covalent drugs against intractable immunology and oncology targets; f5 Therapeutics (San Diego ...

Targeted Therapy for 'Undruggable' Lung Cancer Stems ... - UCSF

Unlike most targeted therapies, the new drugs targeting the cysteine point mutation do not affect the KRAS protein found in normal cells. This ...

New Class of Molecular Glues Could Reshape Cancer Drug Discovery

New Class of Molecular Glues Could Reshape Cancer Drug Discovery · Drugging the Undruggable: Targeted Protein Degradation · Next-Generation ...

Science - Monte Rosa Therapeutics

Pioneering Therapies for Cancer and Beyond – Our drug ... Traditional small molecule inhibitor drugs fall short, leaving approximately 85% of proteins undruggable ...

Angela Koehler takes on the most challenging drug targets | MIT News

... drug certain undruggable targets. Much of her work centers on a protein called Myc, which is overexpressed in about 70 percent of cancers.