ETV6|PDGFRB and FIP1L1|PDGFRA stimulate human ...

Pdgfra marks a cellular lineage with distinct contributions to ... - eLife

... activation of a gain-of ... (2013) Progenitor cells identified by PDGFR-alpha expression in the developing and diseased human heart.

Myeloid/Lymphoid Neoplasms with ETV6::PDGFRB Fusion Gene

TKI targets the kinase domain of ETV6::PDGFRB protein and blocks the constitutive activation ... ETV6-PDGFRB and FIP1L1-PDGFRA stimulate human ...

platelet derived growth factor receptor beta | Type III RTKs

The experiments measuring the ability of PDGF RTK inhibitor to inhibit PDGFR autophosphorylation were carried out in intact human cells, so it ...

Autocrine PDGFR signaling promotes mammary cancer metastasis

Undiluted EpRasXT cell–conditioned medium contained 3.7–4.9 ng/ml PDGF — known to maximally stimulate proliferation of primary human fibroblasts ...

PDGFRA (platelet-derived growth factor receptor, alpha polypeptide)

Proteins · Description. Size: 1089 amino acids; molecular weight: 122670 Da. · Expression. PDGFR expression is characteristic of various ...

An overview of agents and treatments for PDGFRA-mutated ...

Activation or inhibition of these pathways influences cellular proliferation, angiogenesis, and apoptosis. PDGF, platelet-derived growth factor; PDGFR, platelet ...

Genomics of PDGFR-rearranged hypereosinophilic syndrome

... PDGF receptor gene, PDGFRA or PGDFRB, most frequently FIP1L1::PDGFRA. Patients with PDGFR-rearranged HES are overwhelmingly males, and the ...

Myeloid and lymphoid neoplasms with eosinophilia ... - Europe PMC

... PDGFRA leading to constitutive activation. ... It should be noted that neoplasms associated with rearrangement of PDGFRA or PDGFRB share some characteristics with ...

Role of PDGF receptor-α during human cytomegalovirus entry into ...

For example, the receptor increased the portion of AD169-infected ARPE-19 cells from 2.1 to 95%, and for Merlin (pAL1111) the increase was from ...

Mechanism of PDGFR/Tel/ETV-6 Activation - YouTube

... ETV6 (i.e. translocation-Ets-leukemia virus) protein is a transcription factor that in humans is encoded by the ETV6 (previously known as ...

PDGFRA - DISEASES

Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of ...