Scaling cell culture processes

Scaling Fed-Batch and Perfusion Antibody Production Processes in ...

Variations usually occur in cell culture processes due to the fact that the flow is not fully turbulent under typical cultivation conditions, especially at the ...

Scale-Down Models for Microbial and Mammalian Cell Culture ...

The key unit operations for both mammalian and microbial processes are discussed along with the general scale-down principles and parameters for each stage.

How Scale-Up Benefits a Clinical Program to get Results

These include the Repligen XCell™ ATF System (a cell retention device that attaches to the bioreactor to deliver high cell density and process intensification), ...

Univercells Technologies by Donaldson launches the scale-X ...

Univercells Technologies by Donaldson launches the scale-X™ nexo mini bioreactor for cost-efficient, scalable cell culture process development ...

A 3D Sphere Culture System Containing Functional Polymers for ...

Utilizing human pluripotent stem cells (hPSCs) in cell-based therapy and drug discovery requires large-scale cell production.

The highest quality cell culture ingredients and custom solutions

Evonik is a global cell culture partner to the biopharmaceutical industry ... Intensified and high-performing biopharma processes have raised the bar on the ...

Adherent & Suspension Cell Culture in Bioprocessing

Upstream processing with adherent cells starts with culturing a chosen adherent cell line, a virus type, and targeting what the product will be.

Leaving Flatland Behind – A View from Experience in 3D Adherent ...

... cells and exosomes/extracellular vesicles (EVs) than 2D planar cell culture. ... At small scale, a 2D R&D process performed for ~100 million cells ...

Cell culture pilot plant research facility

Our services include: · development and scale-up of batch, fed-batch or perfusion cell culture processes up to 500 L scale for biologics ...

Advanced Approaches for Developing and Optimizing Perfusion ...

Today, perfusion cell culture technology has improved since its introduction into large-scale manufacturing decades ago, yet fed- batch processes still remain ...

Developing A Continuous Large-Scale Perfusion Cell Culture Process

Perfusion processes enable continuous operation over extended periods of time by constantly providing fresh nutrients for the cells and simultaneously ...

Basic Cell Culture Processes and Procedures - Nikon Healthcare

Cell culture processes and procedures vary depending on the cell type and application. We need to be aware that if cells are not handled in a manner that is ...

Bioproduction- Scale, Bioreactors & Disposables

... scaling up production ... The system can evaluate metabolic-based feed strategies for bench scale cell culture processes across multiple vessels.

Better bioprocess scaleup with Bioreactor Scaler Pro - YouTube

Are you still using the manual input, trial-and-error method when scaling your cell culture process, spending long hours in the lab ...

SCALE-DOWN TECHNOLOGIES FOR PERFUSION CULTURE FOR ...

constant kLa and OTR also failed to produce comparable cell growth performance, demonstrating the complexity of scaling cell culture processes. Mammalian cell.

Large-scale smart bioreactor with fully integrated wireless ... - Science

Unlike the existing cell-bag sensors, the entire sensor system is soft and flexible, which does not interrupt the cell culture process and ...

Quick automation wins in mammalian cell culture - Automata

Automated cell culture systems are able to meet strict standardization requirements, reduce contamination rates, and minimise human error2.

Innovative Vertical-Wheel Impeller Technology - PBS Biotech

Benefits of Vertical-Wheel Mixing for Therapeutic Cells · Process parameters optimized at small scale can be recreated at larger volumes with predictable results ...

PD & Pilot Scale Process Intensification - Sartorius

Efficient process development (PD) including a high-titer cell line, clone selection and optimization, and process characterization is critical to develop a ...

Improving Predictability of Cell Culture Processes During Biologics ...

In the biotechnology industry, commercial manufacturing of biologic drugs occurs in large- scale production bioreactors (15,000L), but process ...