A cell‐based model system links chromothripsis with hyperploidy

A cell-based model system links chromothripsis with hyperploidy

A remarkable observation emerging from recent cancer genome analyses is the identification of chromothripsis as a one-off genomic ...

A cell-based model system links chromothripsis with hyperploidy

Our in vitro system uncovered a propensity of chromothripsis to occur in cells with damaged telomeres, and in particular in hyperploid cells.

Cell‐based model systems for genome instability: Dissecting the ...

Chromothripsis, originally discovered in cancer genomes, constitutes a new class of massive genomic rearrangements, which is characterized by ...

Chromothripsis in cancer | Nature Reviews Cancer

A cell-based model system links chromothripsis with hyperploidy. Mol. Syst. Biol. 11, 828 (2015). Article PubMed PubMed Central Google ...

Chromothripsis: an emerging crossroad from aberrant mitosis to ...

... based model system reveals functional consequences of chromothripsis in human cells ... A cell-based model system links chromothripsis with hyperploidy . Mol.

Chromothripsis, DNA repair and checkpoints defects - ScienceDirect

... chromothripsis in medulloblastoma suggests that chromothripsis scoring ... A cell-based model system links chromothripsis with hyperploidy. Mol. Syst ...

Cell‐based model systems for genome instability: Dissecting the ...

Here, we review a range of model systems for chromothripsis and the mechanistic insights gained from these assays, with a particular focus on chromothripsis in ...

Micronuclei-based model system reveals functional consequences ...

... chromothripsis in human cells. Maja Kneissig · Kristina Keuper ... (2015) A cell-based model system links chromothripsis with hyperploidy.

Emerging Mechanisms of Chromothripsis: Trends in Cell Biology

A renewed model of pancreatic cancer evolution based ... 31. Mardin, B.R. ... A cell-based model system links chromothripsis with hyperploidy.

Comprehensive analysis of chromothripsis in 2,658 human cancers ...

A cell-based model system links chromothripsis with hyperploidy. Mol. Syst. Biol. 11, 828 (2015). Article PubMed PubMed Central Google ...

CTLPScanner: a web server for chromothripsis-like pattern detection

M. et al. A cell-based model system links chromothripsis with hyperploidy. Mol. Syst. Biol. 2015. 11.

Mutational game changer: Chromothripsis and its emerging ...

In addition, the cellular mechanisms underlying chromothripsis also contribute to cellular ... A cell-based model system links chromothripsis with hyperploidy.

Chromothripsis—Explosion in Genetic Science - MDPI

... connection between chromothripsis and cell hyperploidization. Moreover ... A cell-based model system links chromothripsis with hyperploidy. Mol. Syst ...

On the Complexity of Mechanisms and Consequences of ... - Frontiers

Chromothripsis may arise in any cell, including somatic cells, germline cells ... A cell-based model system links chromothripsis with hyperploidy. Mol. Syst ...

Comprehensive analysis of chromothripsis in 2,658 human cancers ...

TP53 deficient cells serve as models to generate chromothripsis in vitro. ... A cell-based model system links chromothripsis with hyperploidy. Mol ...

Chromoanagenesis: cataclysms behind complex chromosomal ...

... based models have the potential to explain many features of chromothripsis ... A cell-based model system links chromothripsis with hyperploidy.

Chromosomal Rearrangements and Chromothripsis: The Alternative ...

A cell-based model system links chromothripsis with hyperploidy. Mol ... system reveals functional consequences of chromothripsis in human cells ...

Chromothripsis in Human Breast Cancer - AACR Journals

In breast cancer, chromothripsis studies based on whole-genome sequencing data are rare. ... A cell-based model system links chromothripsis with hyperploidy . Mol ...

Chromothripsis and Kataegis Induced by Telomere Crisis - Cell Press

35. Mardin, B.R. ∙ Drainas, A.P. ∙ Waszak, S.M. ... A cell-based model system links chromothripsis with hyperploidy. Mol. Syst. Biol. 2015 ...

Copy number variations and constitutional chromothripsis (Review)

... hyperploidy with chromothripsis (31). Ivkov and Bunz (32) ... A cell-based model system links chromothripsis with hyperploidy. Mol ...