Emerging Mechanisms of Chromothripsis

Emerging Mechanisms of Chromothripsis: Trends in Cell Biology

Chromothripsis is a catastrophic event in which one or a few chromosomes are shattered and stitched back together in random order, producing a ...

Rebuilding Chromosomes After Catastrophe - PubMed

Here we review emerging mechanisms underlying chromothripsis with a focus on the contribution of cell division errors caused by centromere dysfunction.

Emerging Mechanisms of Chromothripsis - ScienceDirect.com

Trends. Chromothripsis is a catastrophic event in which one or a few chromosomes are shattered and stitched back together in random order, producing a ...

Emerging Mechanisms of Chromothripsis: Trends in Cell Biology

Abstract. Cancer genome sequencing has identified chromothripsis, a complex class of structural genomic rearrangements involving the apparent ...

Chromothripsis: an emerging crossroad from aberrant mitosis to ...

Moreover, the review will highlight recent advancements in identifying potential therapeutic targets and the underlying molecular mechanisms associated with ...

Emerging Mechanisms of Telomere-Driven Genomic Instability

Chromothripsis is characterized by localized genomic regions containing tens to thousands of rearrangements and it is becoming increasingly apparent that ...

Rebuilding Chromosomes After Catastrophe - UC Library Search

Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis Available Online. Send to. Print. Citation. EndNote. EasyBib. Export RIS.

Emerging Mechanisms of Telomere-Driven Genomic Instability

Chromothripsis and Micronuclei. Micronuclei are extranuclear bodies containing large DNA fragments or whole chromosomes that can serve as markers of genome ...

Chromothripsis in cancer | Nature Reviews Cancer

The eventual breakage of stretched chromosome bridges generates free chromosome ends in the two daughter cells, which can initiate a new round ...

Chromothripsis: A New Mechanism for Rapid Karyotype Evolution

Chromosomal rearrangements are generally thought to accumulate gradually over many generations. However, DNA sequencing of cancer and ...

On the Complexity of Mechanisms and Consequences of ... - Frontiers

In the present review, we focus on the phenomenon of chromothripsis, a new type of complex chromosomal rearrangements. We discuss the challenges of ...

Chromothripsis: an emerging crossroad from aberrant mitosis to ...

This review aims to explore the intricate mechanisms and consequences of chromothripsis, with a specific focus on its association with mitotic ...

[PDF] Rebuilding Chromosomes After Catastrophe - Semantic Scholar

Semantic Scholar extracted view of "Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis." by P. Ly et al.

Chromothripsis: A New Frontier in Cancer Research

Repair mechanisms then try to reassemble the chromosome, but the extent of the damage means that hundreds of distinct mutations are incorporated ...

Emerging Mechanisms of Chromothripsis - NOAA Library and Info ...

Cancer genome sequencing has identified chromothripsis, a complex class of structural genomic rearrangements involving the apparent shattering of an ...

Comprehensive analysis of chromothripsis in 2,658 human cancers ...

Signatures of repair mechanisms in chromothripsis regions ... Chromothripsis: a new mechanism for rapid karyotype evolution. Annu ...

Chromothripsis is a common mechanism driving ... - Genome Biology

Similarly, only two new mutations were identified in a brain metastasis compared to a primary breast tumor [8]. These data suggest that ...

What happens when chromosomes shatter - EMBL-EBI

New insights into chromothripsis. Using cell biology experiments and genome analysis, researchers have now discovered the mechanism by which ...

Chromothripsis: a new molecular mechanism in cancer development

Although both ionizing radiation (Stephens et al., 2011) and premature chromosome compaction during mitosis (Meyerson and Pellman, 2011) have been suggested as ...

Chromoanagenesis: a piece of the macroevolution scenario

Rebuilding chromosomes after catastrophe: emerging mechanisms of Chromothripsis. ... Chromothripsis: a new mechanism for rapid karyotype ...