Metabolism|regulated ferroptosis in cancer progression and therapy

Redox-Regulated Iron Metabolism and Ferroptosis in Ovarian Cancer

Ferroptosis, as a novel treatment for ovarian cancer, remains in the experimental stages, confined to cell line and animal model studies, and has not yet ...

Emerging Roles of Energy Metabolism in Ferroptosis Regulation of ...

Remarkably, the ROS levels in tumor cells are usually elevated compared to normal cells due to the intense metabolic activities, which renders ...

Metabolism-regulated ferroptosis in cancer progression and therapy

AbstractCancer metabolism mainly includes carbohydrate, amino acid and lipid metabolism, each of which can be reprogrammed. These processes interact with ...

What is the role of ferroptosis in cancer?

Recent studies reveal that ferroptosis plays a significant role in tumor suppression, giving us new opportunities for cancer treatment.

Ferroptosis: A New Promising Target for Ovarian Cancer Therapy

[64] found that high-OXPHOS metabolism can enhance the sensitivity of chemotherapy for ovarian cancer and improve the prognosis of patients by upregulating PML ...

Ferroptosis at the crossroads of tumor-host interactions, metastasis ...

Ferroptotic cell death is modulated by many metabolic pathways, such as pathways governing the metabolism of sugars, lipids, amino acids, and ...

Ferroptosis, Acyl Starvation, and Breast Cancer

SIGNIFICANCE STATEMENT Regulation of the metabolism of fatty acids in cancer cells seems to be a promising therapeutic direction. Studies show ...

Glutathione in cancer progression and chemoresistance: an update in

This metabolic response plays a crucial role in helping glycolytic cancer cells to synthesize nucleic acids, coenzymes, ATP and fatty acids and ...

Advances in ferroptosis of cancer therapy - De Gruyter

Ferroptosis is an iron-dependent mode of programmed cell death characterized by Reactive Oxygen Species (ROS) accumulation lipid ...

The Hallmarks of Ferroptosis - Annual Reviews

Ferroptosis is a nonapoptotic, iron-dependent form of cell death that can be activated in cancer cells by natural stimuli and synthetic ...

Ferroptosis Inducers Are a Novel Therapeutic Approach for ...

In the context of prostate cancer, it has been shown that DECR1 is an androgen-regulated survival protein that protects cells from ferroptosis and targeting ...

Mitochondria-mediated Ferroptosis in Diseases Therapy

Mitochondria are vital components of eukaryotic cells, serving important functions in energy production, cellular metabolism, and apoptosis regulation.

Glutathione metabolism in cancer progression and treatment ...

Excess GSH promotes tumor progression, where elevated levels correlate with increased metastasis. In this review, we discuss recent studies that ...

Therapeutic efficacy of ferroptosis in the treatment of colorectal ...

Regulated cell death, including apoptosis, pyroptosis, necroptosis, ferroptosis, autophagy-dependent cell death and neoplastic cell death, is a ...

The Role of Iron Metabolism in Cancer Progression | Science Lab

So far, several small molecules (e.g., erastin and RSL3) have been found to selectively induce ferroptosis in cancer cells. However, phenomena ...

SLC7A9 suppression increases chemosensitivity by inducing ...

SLC7A9 promotes gastric cancer progression by acting as a suppressor of ferroptosis, independent of SLC7A11, which is negatively regulated by p53. Funding. This ...

FERREG: ferroptosis-based regulation of disease occurrence ...

For instance, ferroptosis can effectively kill tumor cells in colorectal cancer, thus inhibiting the malignant progression of cancer [7].

Advances in the study of regulators of ferroptosis in head and neck ...

Thus, the regulation of ferroptosis via iron homeostasis can effectively kill cancer cells by increasing iron uptake, decreasing iron storage ...

Specific redox protein identified as a critical regulator of ferroptosis

Ferroptosis has garnered strong interest due to its therapeutic potential in addressing therapy-resistant and metastasizing cancers, and its ...

Role of ferroptosis in cancer - YouTube

... to restrict tumour growth. Find out more about how inhibiting ferroptosis may open a new direction in therapeutic targeting for cancer ...