Chromothripsis is a common mechanism driving ...

Copy number variations and constitutional chromothripsis (Review)

Several proposed mechanisms have been suggested to underlie chromothripsis, such as p53 inactivation, micronuclei formation, abortive apoptosis ...

Chromothripsis: A driver of gene amplification in cancer

Researchers have used whole-genome sequencing (WGS) to show that chromothripsis is a major driver of circular extrachromosomal DNA amplification.

Chromothripsis - Extensive Chromosomal Rearrangements and ...

Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer. ... Articles in the Open Access Subset are ...

Whole genome sequence analysis links chromothripsis to EGFR ...

24. Kloosterman WP et al. Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer.

A cell‐based model system links chromothripsis with hyperploidy

A remarkable observation emerging from recent cancer genome analyses is the identification of chromothripsis as a one‐off genomic catastrophe, resulting in ...

Chromosomal catastrophe is a frequent event in clinically ...

Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer. Genome Biol. 2011; 12:R103 ...

Chromothripsis in human cancer | EMBL

They could also directly link chromothripsis to common hallmarks of the cancer genome, including oncogene amplification (an increase in the ...

Criteria for Inference of Chromothripsis in Cancer Genomes - CORE

Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer. Genome Biol. 12, R103 ...

Chromothripsis Identified by Copy Number Profiling in a Case of ...

Kloosterman WP, Hoogstraat M, Paling O, TavakoliYaraki M, Renkens I, Vermaat JS, et al. Chromothripsis is a common mechanism driving genomic ...

Chromothripsis and progression‑free survival in metastatic ...

Such genomic rearrangements may drive the development of cancer through several mechanisms, including deletion of tumor suppressor genes and ...

Comprehensive analysis of chromothripsis in 2,658 human ... - bioRxiv

Overall, although kataegis can co- occur with chromothripsis, this co-occurrence is not common ... Chromothripsis as a mechanism driving complex ...

Unbalanced translocations arise from diverse mutational ...

2011). As more germline chromothripsis genomes are being se- quenced, common ... Chromothripsis as a mechanism driving complex de novo structural ...

Shattered and stitched chromosomes—chromothripsis and ...

Chromothripsis was postulated to occur in a single catastrophic event leading to complex genomic rearrangements (Stephens et al., 2011). The ...

Chromothripsis

Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastat- ic colorectal cancer. Genome Biol 2011; 12:R103 ...

Chromoanagenesis: a piece of the macroevolution scenario

The key-features, common to all chromothripsis events ... Chromothripsis as a mechanism driving complex de novo structural rearrangements in the germline.

Chromothripsis-like patterns are recurring but heterogeneously ...

... Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer. Genome Biol. 2011, 12 (10): R103-10.1186/gb ...

(PDF) On the Complexity of Mechanisms and Consequences of ...

In the present review, we focus on the phenomenon of chromothripsis, a new type of complex chromosomal rearrangements. We discuss the challenges of ...

Chromothripsis - CiteSeerX

Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastat- ic colorectal cancer. Genome Biol 2011; 12:R103;. PMID:22014273 ...

Chromothripsis is a common mechanism driving genomic ...

Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer.

City Research Online - City, University of London

Overall, although kataegis can co-occur with chromothripsis, this co-occurrence is not common. ... Chromothripsis as a mechanism driving complex de novo ...